Results 81 to 90 of about 267,134 (305)

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Effects of caffeine on sleep quality and daytime functioning

Risk Management and Healthcare Policy, 2018
Frances O’Callaghan,1 Olav Muurlink,2,3 Natasha Reid4 1School of Applied Psychology, Griffith Health, Griffith University, Southport, QLD, Australia; 2School of Business and Law, Central Queensland University, Brisbane, QLD, Australia; 3Griffith ...
O'Callaghan F, Muurlink O, Reid N
doaj  

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Effect Of Caffeine On Exercise Performance: Current Review

Türk Spor ve Egzersiz Dergisi, 2021
Caffeine is an ergogenic supplement that has been attracting attention in the sports community for many years. It has been proven in many studies that coffee consumption has a positive effect on exercise performance.
Yusuf Buzdağlı, Günay Eskici, Erdinç Şıktar, Aslıhan Tekin   +3 more
doaj  

Sudden Caffeine Withdrawal Triggers Migraine—A Randomized Controlled Trial

Frontiers in Neurology, 2020
Objective: Assessing the effects of caffeine withdrawal on migraine.Background: The effects of caffeine withdrawal on migraineurs are at large unknown.Methods: This was a randomized, double-blind, crossover study (NCT03022838), designed to enroll 80 ...
Karl B. Alstadhaug, Karl B. Alstadhaug, Hilde Karen Ofte, Kai Ivar Müller, Kai Ivar Müller, Anna P. Andreou, Anna P. Andreou   +6 more
doaj   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

Design, formulation and evaluation of caffeine chewing gum

Advanced Biomedical Research, 2013
Background: Caffeine which exists in drinks such as coffee as well as in drug dosage forms in the global market is among the materials that increase alertness and decrease fatigue.
Abolfazl Aslani, Fatemeh Jalilian
doaj   +1 more source

UV micro-irradiation of the Chinese hamster cell nucleus and caffeine post-treatment immunocytochemical localization of DNA photolesions in cells with partial and generalized chromosome shattering [PDF]

, 1983
UV micro-irradiation of a small part of the Chinese hamster nucleus and caffeine post-incubation often results in shattered chromosomes at the first post-irradiation mitosis.
Cornelis, Cornelis, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Deaven, Fukuda, Gray, Hsu, Kihlman, Lehmann, Nilsson, Stack, Stubblefield, Taylor, Zorn, Zorn   +26 more
core   +1 more source