Results 81 to 90 of about 164,322 (311)
Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
Configurational studies of complexes of tea catechins with caffeine and various cyclodextrins. [PDF]
, 2012 A suspension of an equimolecular amount of ENT-gallocatechin-3-O-gallate ( ENTGCg) and caffeine in water afforded two kinds of crystals, which were 1 : 2 and 2 : 2 complexes of ENTGCg and caffeine.
46107 +11 more
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Caffeine Consumption and Mortality in Diabetes: An Analysis of NHANES 1999–2010
Frontiers in Endocrinology, 2018 Aim: An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the effect of coffee consumption in diabetes remains unclear.
João Sérgio Neves +9 more
doaj +1 more source
Caffeine and its potential role in attenuating impaired wound healing in diabetes
, 2015 Diabetes is a common disorder that is characterized by high blood glucose levels, polyuria, and polydipsia. As a result of chronically elevated blood glucose, impaired wound healing is one of the many serious issues that can occur in diabetic patients ...
Zeinab Bonyanian +3 more
core +1 more source
Intelligent Automation Improved Efficiency in Pharmacovigilance Safety Signal Assessment
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacovigilance is the science involving the detection, assessment, understanding, and prevention of adverse events associated with drugs, biologics, or medical devices. In pharmacovigilance, information that suggests a new potential causal relationship between an intervention and an adverse event is called a safety signal. Following their detection,
Jeffrey Warner +3 more
wiley +1 more source
Design, formulation and evaluation of caffeine chewing gum
Advanced Biomedical Research, 2013 Background: Caffeine which exists in drinks such as coffee as well as in drug dosage forms in the global market is among the materials that increase alertness and decrease fatigue.
Abolfazl Aslani, Fatemeh Jalilian
doaj +1 more source
Assessing the reinforcing effects of caffeine : the self-administrtion of caffeine by rats [PDF]
, 2009 Caffeine is the most widely consumed psychoactive drug, with the prevalence of use approaching 80% of the world's population. In stark contrast to most stimulants, caffeine is considered an innocuous agent with advantageous behavioral effects ...
NC DOCKS at The University of North Carolina Wilmington +1 more
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Caffeine-mixed alcohol exposure in adolescence increases natural reward consumption and preference.
, 2016 Adolescent exposure to caffeine-mixed alcohol (15 mg/kg caffeine, 1.5 g/kg alcohol, A+C) or water (H2O) altered natural reward consumption and preference in adulthood (n = 6–8 per group).
Meridith T. Robins (3159948) +2 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke +12 more
wiley +1 more source
Effects of Caffeine on Arithmetic Performance ーA study in student Laboratoryー [PDF]
, 2001 看護大学1年次の学生85名(男13名,女72名)に,市販のカフェイン抜きコーヒーとカフェイン入りコーヒーを飲用させ,単純な計算能力及び心拍数に対するカフェインの作用について検討した.練習効果による計算能力の向上がほぼ一段落する時点でコーヒーを飲用させた.その結果,飲用後20分近く経過した時点で,カフェイン入りコーヒー飲用群の計算能力はカフェイン抜きコーヒー飲用群を有意に上回ること,この効果は,飲用後1時間を過ぎ,カフェイン抜きコーヒー飲用群では計算能力の低下が見られるようになった時点でもなお認められ ...
イマイ, ショウイチ +7 more
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