Results 171 to 180 of about 262,566 (370)

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek   +9 more
wiley   +1 more source

Green Electrochemical Point‐of‐Care Devices: Transient Materials and Sustainable Fabrication Methods

open access: yesChemSusChem, Volume 18, Issue 7, April 1, 2025.
The deployment of point‐of‐care diagnosis may lead to sustainability concerns due to the complex management of generated waste. This review examines transient materials and printing technologies to enhance the sustainability of electrochemical point‐of‐care devices, providing examples of components incorporating transient materials for eco‐friendly ...
David Batet, Gemma Gabriel
wiley   +1 more source

Mechanochemical Generation of Active Pd/BippyPhos Catalyst for Efficient CN Cross‐Coupling in Air

open access: yesChemSusChem, EarlyView.
A solvent‐free, solid‐state Buchwald–Hartwig amination is developed using [Pd(π‐cinnamyl)Cl]2 and bulky electron‐rich phosphines. The active catalyst forms without solvent or inert atmosphere, as confirmed by solid‐state 31P nuclear magnetic resonance.
Deniz Karabiyikli   +7 more
wiley   +1 more source

Detection of the GH analog somatrogon in sports drug testing: Immunological approaches and LC‐HRMS/MS

open access: yesDrug Testing and Analysis, Volume 17, Issue 5, Page 634-646, May 2025.
The detectability of the GH analog somatrogon with approved doping control immunoassays for hGH and hCG was evaluated and a both sensitive and specific qualitative detection assay employing affinity purification, tryptic digestion, and LC‐HRMS/MS was developed to confirm the presence of the drug in suspicious serum samples. Abstract Due to the presumed
Katja Walpurgis   +5 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

open access: yesDrug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis   +2 more
wiley   +1 more source

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