Results 111 to 120 of about 33,292 (260)

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

DNA Repair Pathway Variants Are Enriched in Individuals with Biallelic AAGGG CANVAS and RFC1‐Related Disease

Movement Disorders, EarlyView.
Abstract Background Cerebellar ataxia, neuropathy and vestibular are flexia syndrome (CANVAS) and RFC1‐related disease are most commonly caused by biallelic AAGGG repeat expansions in RFC1. The high population frequency of this expansion compared to the frequency of CANVAS suggests incomplete penetrance.
Xuemin Wang, Liam G. Fearnley, Kayli C. Davies, Penny Snell, Stuart Lee, Victoria E. Jackson, Justin Read, Michael Milton, Ian H. Harding, Martin B. Delatycki, David J. Szmulewicz, Paul J. Lockhart, Melanie Bahlo, Haloom Rafehi   +13 more
wiley   +1 more source

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Movement Disorders, EarlyView.
Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis.
Michela Leocadi, Nicola Z. Hobbs, Mena Farag, Michael J. Murphy, Kate Fayer, Olivia Thackeray, Harry Knights, James B. Rowe, Trevor W. Robbins, Barbara J. Sahakian, Geraint Rees, Rachael I. Scahill, Sarah J. Tabrizi, Christelle Langley   +13 more
wiley   +1 more source

Expanded ATXN3 CAG Repeat is Stable in Human Purkinje Cells

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by an abnormally long polyglutamine‐encoding CAG repeat in the ATXN3 gene. Objectives We aimed to determine whether somatic expansion of the mutant ATXN3 (mATXN3) CAG repeat is present in the output cell of the cerebellar cortex, the Purkinje cell (PC), in ...
Hasnahana Chetia, Laura Kus, Erika Sipos, Nathaniel Heintz, Kert Mätlik   +4 more
wiley   +1 more source

Generative MR Multitasking With Complex‐Harmonic Cardiac Encoding: Bridging the Gap Between Gated Imaging and Real‐Time Imaging

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop a unified image reconstruction framework that bridges real‐time and gated cardiac MRI, including quantitative MRI. Methods We introduce generative multitasking, which learns subject‐ and dataset‐specific implicit neural temporal bases from sequence timings and an interpretable latent space for cardiac and respiratory motion.
Xinguo Fang, Anthony G. Christodoulou
wiley   +1 more source

Growth and human milk intake outcomes from postdischarge feedings among very‐low‐birth‐weight preterm infants: A systematic review

Nutrition in Clinical Practice, EarlyView.
Abstract Background Preterm infants of <34 weeks gestation or <1500 g are at risk for postnatal growth failure and often require nutrition support after discharge. Despite expert recommendations for postdischarge human milk (HM) fortification or nutrient‐enriched formula feeding, the effects of current feeding strategies on growth and HM intake remain ...
Tara Rebele, Allison Gomes, Melanie Newkirk, Mina Ghajar, Laura Byham‐Gray, Jane Ziegler   +5 more
wiley   +1 more source

A Schizophrenia‐Spectrum Presentation with Panda Sign: Huntington's Disease Confirmed, Wilson Disease Excluded

Movement Disorders Clinical Practice, EarlyView.
Eva‐Maria Tsapakis, Georgia Zafeiridou, Elizabeth Psoma, Angelos Giannoutsos, Andreas Kiryttopoulos, Konstantinos N. Fountoulakis   +5 more
wiley   +1 more source

An open‐source pipeline for longitudinal single‐cell tracking and cell‐cycle/migration coupling analysis for neurotherapeutic screening

Neuroprotection, EarlyView.
Integrated experimental and computational pipeline for longitudinal single‐cell tracking and cell‐cycle dynamics analysis. Schematic of the FUCCI (Fluorescence Ubiquitination‐based Cell Cycle Indicator) reporter system. The construct is driven by the CAG promoter (CMV enhancer + chicken β‐actin promoter) and encodes two fusion proteins: mKO2‐Cdt1 ...
Neha Chandra, Matthew Yang, Hailey Wang, Miroslaw Janowski, Piotr Walczak, Cedric Allier, Yajie Liang   +6 more
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

Small, EarlyView.
A biomimetic microfluidic tumor‐on‐chip platform was designed to uncover subtype‐dependent responses to nanoparticle‐mediated photothermal therapy in breast cancer spheroids. The platform establishes a physiologically relevant and controllable 3D system for precision evaluation of nanophotothermal cancer therapies.
Camila A. Salvego, Hasti Honari, Anastasiia Dubrova, Stéphanie Descroix, Martha S. Ribeiro, Aurore V. Walle, Claire Wilhelm   +6 more
wiley   +1 more source