Results 131 to 140 of about 33,292 (260)

Neural Networks and Multivariate Analysis Based on Geochemical Data to Determine Stone Provenance From Ancient Calabrian Quarries (Southern Italy)

Archaeometry, EarlyView.
ABSTRACT This study shows an innovative approach to determine the origin of some Calabrian rocks quarried used in ancient times. Twenty‐five quarries, distributed in all the Calabrian provinces (Southern Italy), were studied and sampled. Ten samples were taken from each quarry, for a total of 250 samples.
Domenico Miriello, Stefano Columbu, Raffaella De Luca, Marco Lezzerini, Mirco Taranto, Fabrizio Antonelli   +5 more
wiley   +1 more source

Genetic or pharmacological disruption of the MSH3 Y245/K246 IDL binding pocket slows CAG repeat expansion. [PDF]

NAR Mol Med
Goold R, Donaldson J, Gidney F, Goff P, Hamilton J, Elmasri M, Coupland L, Flower M, Tabrizi SJ.   +8 more
europepmc   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. [PDF]

Nat Commun
Collotta G, Gatti M, Ungureanu IM, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA.   +16 more
europepmc   +1 more source

m¹A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. [PDF]

Nature, 2023
Sun Y, Dai H, Dai X, Yin J, Cui Y, Liu X, Gonzalez G, Yuan J, Tang F, Wang N, Perlegos AE, Bonini NM, Yang XW, Gu W, Wang Y.   +14 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding. [PDF]

Nat Commun
Mathews EW, Coffey SR, Gärtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Bennett CF, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Beuzer P, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB.   +26 more
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

DNA extrusion size determines pathway choice during CAG repeat expansion. [PDF]

Nucleic Acids Res
Bhatia M, Phadte AS, Lakhina A, Monte Carlo Iii AR, Barndt S, Pluciennik A.   +5 more
europepmc   +1 more source

In Vitro Synthesis and Cloning of Long CAG Repeats

BioTechniques, 1996
Jared M. Ordway, Peter J. Detloff
openaire   +3 more sources