The Effect of CAG Repeats within the Non-Pathological Range in the HTT Gene on Cognitive Functions in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment [PDF]
Diagnostics, 2021 The Huntingtin gene (HTT) is within a class of genes containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. Individuals with less than 35 repeats are not associated with HD.
Salvatore Mazzeo +2 more
exaly +4 more sources
Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline [PDF]
Journal of Ovarian Research, 2023 Background To study whether CAG repeat polymorphism of androgen receptor (AR) contributes to the risk of polycystic ovarian morphology (PCOM) with antral follicle count (AFC) ≥ 20 in the context of new international guideline of polycystic ovary syndrome
Xueqi Yan +12 more
doaj +2 more sources
Long tract of untranslated CAG repeats is deleterious in transgenic mice. [PDF]
PLoS ONE, 2011 The most frequent trinucleotide repeat found in human disorders is the CAG sequence. Expansion of CAG repeats is mostly found in coding regions and is thought to cause diseases through a protein mechanism.
Ren-Jun Hsu +6 more
doaj +2 more sources
CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study [PDF]
Frontiers in Psychiatry, 2022 Objective:HTT is a gene containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. HTT genes with <35 repeats are not associated with HD.
Valentina Moschini +18 more
doaj +2 more sources
The effect of CAG repeats length on differences in hirsutism among healthy Israeli women of different ethnicities. [PDF]
PLoS ONE, 2018 PURPOSE:Variations in the degree of hirsutism among women of different ethnic backgrounds may stem from multiple etiologies. Shorter length of the polymorphic CAG repeats of the androgen receptor (AR) gene may be associated with increased activity of the
Naomi Weintrob +7 more
doaj +2 more sources
Comparison of NGS panel and Sanger sequencing for genotyping CAG repeats in the AR gene [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background The androgen receptor (AR) is a nuclear receptor, encoded by the AR gene on the X chromosome. Within the first exon of the AR gene, two short tandem repeats (STR), CAG and GGC, are a source of polymorphism in the population.
Maria Santa Rocca +7 more
doaj +2 more sources
Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats. [PDF]
PLoS ONE, 2011 In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene.We analysed the structure of ...
Daniel Duzdevich +7 more
doaj +4 more sources
Short CAG repeat variation as a regulatory factor in health and disease [PDF]
Frontiers in GeneticsShort cytosine-adenine-guanine (CAG) trinucleotide repeats, which encode polyglutamine (polyQ) tracts, are prevalent features of genes enriched in transcriptional and regulatory functions, including the androgen receptor (AR) and huntingtin (HTT).
Jacob R. Manjarrez
doaj +2 more sources
Identification of Proteins Specifically Assembled on a Stem-Loop Composed of a CAG Triplet Repeat
DNA, 2023 Human genomic DNA contains a number of diverse repetitive sequence motifs, often identified as fragile sites leading to genetic instability. Among them, expansion events occurring at triplet repeats have been extensively studied due to their association ...
Robert P. Fuchs +3 more
doaj +1 more source
Artery Research, 2020 Background Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM) [1]. Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor resistance ...
Adrian Heald +12 more
doaj +2 more sources