Results 21 to 30 of about 25,953 (158)
The number of androgen receptor CAG repeats and mortality in men
The Aging Male, 2022 Introduction The androgen receptor (AR) mediates peripheral effects of testosterone. Evidence suggests that the number of CAG repeats in exon-1 of the AR gene negatively correlates with AR transcriptional activity.
Adrian Heald +8 more
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Androgen Receptor CAG Repeats and Prostate Cancer [PDF]
American Journal of Epidemiology, 2002 Prostate cancer is the most common nonskin malignancy and the second leading cause of cancer deaths among men in the United States. Prostate cancer ([Mendelian Inheritance in Man 176807]) has a complex etiology; presently, age, ethnicity, and family history are the most consistently reported risk factors associated with disease.
Kevin A, Nelson, John S, Witte
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Сахарный диабет, 2015 In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. Genomic effects of testosterone caused by the length of CAG repeats polymorphism in the androgen receptor (AR) gene.Aim.
Irina Alekseevna Khripun +2 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by expansion of cytosine-adenine-guanine (CAG)-trinucleotide repeats in causative genes.
Tomoki Hirunagi +14 more
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Function of AGCA tetrads in (CAG)n repeats [PDF]
Nucleic Acids Symposium Series, 2004 We investigate the structural properties of d(CAG)n repeats in d[CG(CAG)4CG)]*d[CG(CTG)4CG]. The crystals diffract up to 3.5 A and completeness of data is only 60%. We also measure Tm-UV and CD spectra and gel electrophoresis of this oligomer.
Kazimierz, Grzeskowiak +4 more
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Huntington's Disease with Small
Movement Disorders, 2023 AbstractBackgroundCarriers of small cytosine‐adenine‐guanine (CAG) repeats below 39 in the HTT gene are traditionally associated with milder Huntington's disease, but their clinical profile has not been extensively studied.ObjectiveTo study the phenotype of CAG36‐38 repeat carriers.MethodsWe included 35 patients and premanifest carriers of CAG36‐38 ...
Anna Heinzmann +10 more
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DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases [PDF]
Neurotherapeutics, 2021 CAG repeat expansion is the genetic cause of nine incurable polyglutamine (polyQ) diseases with neurodegenerative features. Silencing repeat RNA holds great therapeutic value. Here, we developed a repeat-based RNA-cleaving DNAzyme that catalyzes the destruction of expanded CAG repeat RNA of six polyQ diseases with high potency.
Nan Zhang +10 more
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PLoS ONE, 2019 Amplification of a CAG trinucleotide motif (CTG18.1) within the TCF4 gene has been strongly associated with Fuchs Endothelial Corneal Dystrophy (FECD).
Eric D Wieben +12 more
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Phenotypic features of a Russian family with spinocerebellar ataxia type 6 from Khabarovsk Krai
Анналы клинической и экспериментальной неврологии, 2021 The article presents a familial case of spinocerebellar ataxia type 6, consisting of 7 people across 4 generations from a mixed marriage of Yakut, Even, and Russian ethnicities, living in Khabarovsk Krai.
Tatyana N. Proskokova +3 more
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Hematology/Oncology and Stem Cell Therapy, 2009 BACKGROUND: Endometriosis and uterine leiomyomas are leading hormone responsive, benign uterine disorders responsible for high morbidity in women of reproductive age group. A polymorphic (CAG)n repeat length located in exon 1 of the androgen receptor (AR)
Noor Ahmad Shaik +4 more
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