Results 61 to 70 of about 96,981 (224)

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer

BMC Cancer
Background As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease management.
Jiahong Tan, Lin Zhao, Daoqi Wang, Xiaodie Wu, Yongxiang Bi, Hanying Wang, Na Ma, Dehong Yang, Wei Dong, Jie Zhang   +9 more
doaj   +1 more source

Revised metallicity classes for low-mass stars: dwarfs (dM), subdwarfs (sdM), extreme subdwarfs (esdM), and ultra subdwarfs (usdM)

, 2007
The current classification system of M stars on the main sequence distinguishes three metallicity classes (dwarfs - dM, subdwarfs - sdM, and extreme subdwarfs - esdM).
Bessel M. S., Gizis J. E., Michael M. Shara, R. Michael Rich, Schweitzer A., Sebastien Lepine   +5 more
core   +1 more source

Interactions Between O‐Phospho‐L‐Serine and Trivalent Metal Ions: Studies in Solution and Solid State

European Journal of Inorganic Chemistry, EarlyView.
The interaction between the phosphorylated amino acid O‐phospho‐L‐serine and trivalent ions of f‐elements such as La3+, Eu3+, and Lu3+, supplemented by Y3+, has been studied in aqueous media. Nuclear magnetic resonance (NMR) spectroscopy in solution and in the solid state examined complex formation from the ligand perspective, while time‐resolved laser‐
Jonas Kunigkeit, Björn Drobot, Dominik Goldbach, Silvia Paasch, Gudrun Scholz, Thorsten Stumpf, Eike Brunner, Jerome Kretzschmar   +7 more
wiley   +1 more source

Nonclassical Congenital Adrenal Hyperplasia and Pregnancy

Case Reports in Endocrinology, 2015
Objective. The most common form of congenital adrenal hyperplasia (CAH) is 21-hydroxylase (21-OH) deficiency due to mutation of the CYP21A2 gene. Patients with nonclassical CAH (NC-CAH) are usually asymptomatic at birth and typically present in late ...
Neslihan Cuhaci, Cevdet Aydın, Ahmet Yesilyurt, Ferda Alpaslan Pınarlı, Reyhan Ersoy, Bekir Cakir   +5 more
doaj   +1 more source

Connectivity between the seizure onset zone and the thalamus correlates with seizure outcomes in thalamic responsive neurostimulation

Epilepsia, EarlyView.
Abstract Objective Thalamic responsive neurostimulation (RNS) is a surgical option for patients with drug‐refractory epilepsy. However, it is unclear whether thalamic connectivity with the seizure onset zone (SOZ) has a role in clinical outcomes. Here, we aim to investigate the clinical utility of the connectivity between the SOZ and the thalamus for ...
Varun R. Subramaniam, Andy Ho Wing Chan, Lara Marcuse, Madeleine Fields, Maite La Vega‐Talbott, Daniel D. Cummins, Juan A. Barcia, Hesham T. Ghonim, Lakshman Arcot Jayagopal, Yunju Im, Saadi Ghatan, Fedor Panov, Josue M. Avecillas‐Chasin   +12 more
wiley   +1 more source

Presentation and Management of Addison's Disease in a 10‐Year‐Old Boy: A Case Report

iLABMED, EarlyView.
ABSTRACT Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder characterized by impaired adrenal hormone production. We report a case of a 10‐year‐old boy with congenital adrenal hyperplasia and secondary Addison's disease on long‐term corticosteroid therapy who presented with recurrent non‐bilious vomiting, low‐grade fever,
Srinivasan Sivannan, Mohammed Azhar Hussain, Syed Mohammed Hussaini, Pasumarthi Tejashree, Karthikeyan Elumalai   +4 more
wiley   +1 more source

Increased cardiovascular and metabolic morbidity in patients with 21-hydroxylase deficiency : a Swedish population-based national cohort study [PDF]

, 2017
CONTEXT: Congenital adrenal hyperplasia (CAH) is lethal in its most severe forms if not treated with glucocorticoids. However, glucocorticoids may increase the risk of cardiovascular and metabolic morbidity.
Almqvist, Catarina, Falhammar, Henrik, Frisén, Louise, Hirschberg, Angelica L., Nordenskjöld, Agneta, Nordenström, Anna, Norrby, Christina   +6 more
core   +1 more source

Bioelectrochemical single reactor for reductive and oxidative removal of trichloroethylene from contaminated groundwater

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Chlorinated aliphatic hydrocarbons such as trichloroethylene (TCE) are persistent groundwater contaminants due to improper disposal and low biodegradability. This work presents an innovative bioelectrochemical system for the integrated reductive/oxidative removal of TCE from contaminated water, implemented in a single tubular ...
Maria Presutti, Geremia Sassetto, Angela Marchetti, Giulia Simonetti, Marco Petrangeli Papini, Marco Zeppilli   +5 more
wiley   +1 more source

A Rare Case of Co-occurrence of Multiple Endocrine Neoplasia Syndrome and Congenital Adrenal Hyperplasia

Ожирение и метаболизм
Multiple endocrine neoplasia type 1 (MEN1) and congenital adrenal hyperplasia (CAH) are rare monogenic hereditary endocrinopathies with a prevalence of 1–9 cases per 100,000 and 9–15 cases per 100,000, respectively.
A. S. Bondarenko, E. O. Mamedova, Zh. E. Belaya, G. A. Melnichenko   +3 more
doaj   +1 more source