Results 71 to 80 of about 11,276 (296)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Estudo comparativo da eficácia do etanol e do ácido L-glutâmico na prevenção da calcificação das cúspides e parede aórtica porcina: estudo experimental em ratos Comparative study on the efficacy of ethanol and of l-glutamic acid for preventing calcification of pig cusps and aortic wall: experimental study in rats

Brazilian Journal of Cardiovascular Surgery, 2002
INTRODUÇÃO: As cúspides porcinas tratadas com glutaraldeído (GDA) são um dos tecidos biológicos mais utilizados em biopróteses, porém a calcificação tardia pós-implante constitui a causa predominante de sua falência.
George Ronald Soncini da ROSA, Francisco Diniz Affonso da COSTA, Lismari MESQUITA, Iseu de Santo Elias Affonso da COSTA   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Exploring associations between breast tumor inflammatory gene expression and mammographic calcifications and masses in a community-based population

Scientific Reports
Mammography is important for breast cancer detection, and calcifications and masses are the most common mammographic features. In this exploratory study, we evaluated the association between these findings and immune gene expression to determine the role
Nathan C. Shaul, Melissa A. Troester, Alina M. Hamilton, Sheila S. Lee, Louise M. Henderson, Sarah J. Nyante   +5 more
doaj   +1 more source

Calcification, a physiological process to be considered in the context of the whole organism [PDF]

, 2009
Abstract. Marine organisms that produce calcium carbonate structures are predicted to be most vulnerable to a decline in oceanic pH (ocean acidification) based on the understanding that calcification rates will decrease as a result of changes in the seawater carbonate chemistry thereby reducing carbonate ion concentration (and associated saturation ...
Findlay, H. S., Wood, H. L., Kendall, M. A., Spicer, J. I., Twitchett, R. J., Widdicombe, S.   +5 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Synthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineering [PDF]

, 2014
Novel, injectable, biodegradable macromer solutions that form hydrogels when elevated to physiologic temperature via a dual chemical and thermo-gelation were fabricated and characterized.
Mikos, Antonios G., Kasper, F. Kurtis, Engel, Paul S., Watson, Brendan M.   +3 more
core   +1 more source

Eficácia do AlCl3 e etanol na prevenção da calcificação de fragmentos da parede aórtica porcina fixados em GDA Efficacy of AlCl3 and ethanol in the prevention of calcification of fragments of porcine aortic wall fixed in GDA

Brazilian Journal of Cardiovascular Surgery, 2006
OBJETIVO: Avaliar a eficácia do cloreto de alumínio, isoladamente ou em associação com o etanol, na prevenção da calcificação e da resposta inflamatória de fragmentos de parede aórtica porcina fixada em glutaraldeído (GDA), implantados no tecido ...
Evandro Antonio Sardeto, Francisco Diniz Affonso da Costa, Iseu do Santo Elias Affonso da Costa, João Gabriel Roderjan, Eduardo Discher, Ricardo Alexandre Schneider, Carlos Henrique Gori Gomes, Claudinei Colattusso, Daniel Précoma, Andrea Dumsch, Sergio Veiga Lopes, Jairo Leal   +11 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Calcification of the human heart valves: a mineralogical approach [PDF]

, 2010
Normal physiologic processes result in development of mineralized tissue. Bones and tooth enamel are the main example of biominerals. Pathologic processes lead to calcification of the atherosclerotic plaques, kidney and salivary stones and other ...
CAVARRETTA, Elena, L. Salvador, COTTIGNOLI, VALENTINA, MARAS, Adriana, C. Valfre   +4 more
core