Results 81 to 90 of about 11,276 (296)

Investigating the role of culture conditions on hypertrophic differentiation in human cartilage endplate cells [PDF]

, 2020
Cartilage endplate degeneration/calcification has been linked to the onset and progression of intervertebral disc degeneration and there is a critical need to understand mechanisms, such as hypertrophic differentiation, of cartilage endplate degeneration/
Yeater, Taylor, Katherine Lakstins, Lauren Arnold, Safdar Khan, Devina Purmessur, Lakstins, Katherine, Hoyland, Judith, Khan, Safdar, Purmessur, Devina, Judith A. Hoyland, Arnold, Lauren, Taylor Yeater   +11 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Beyond deficiency:Potential benefits of increased intakesof vitamin K for bone and vascular health [PDF]

, 2004
Vitamin K is wellknown for its role in the synthesisof a number of blood coagulationfactors.During recent years vitaminK-dependent proteins werediscovered to be of vital importancefor bone and vascular health.Recommendations for dietary vitaminK intake ...
Vermeer, C, Weber, P, Zittermann, A, Shearer, M, Szulc, P, Walter, P, Stocklin, E, Bolton-Smith, C, Rambeck, W, Hodges, S   +9 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Health and Economic Consequences of Sevelamer Use for Hyperphosphatemia in Patients on Hemodialysis [PDF]

, 2005
ObjectivesThe safety and efficacy of sevelamer hydrochloride in binding phosphate in patients with end-stage renal disease and its ability to attenuate the progression of cardiac calcification have been well documented but not the longer-term health and ...
Huybrechts, Krista F., Wilson, David A., Caro, J. Jaime, O'Brien, Judith A.   +3 more
core   +1 more source

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries [PDF]

, 2014
Background: Ectopic vascular calcifications represent a major clinical problem associated with cardiovascular disease and mortality. However, the mechanisms underlying pathological vascular calcifications are largely unknown hampering the development of ...
Alves, RDAM, Eijken, Marco, van de Peppel, Jeroen, van Leeuwen, Hans; id_orcid, van Leeuwen, Hans, van de Peppel, Jeroen; id_orcid   +5 more
core   +4 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Decreased expression of miRNAs and downstream genes in thoracic aorta from CKD animals. [PDF]

, 2013
Thoracic aorta were collected at 35 weeks of age from CKD (n = 8) and normal rats (n = 8) and total RNA was isolated and miRNA expression determined by real time PCR and normalized by U6.
Neal X. Chen (575211), Kraiwiporn Kiattisunthorn (587110), Kalisha D. O'Neill (587111), Sharon M. Moe (306717), Matthew R. Allen (271081), Ranjani N. Moorthi (587112), Xianming Chen (75957), Vincent H. Gattone II (286857)   +7 more
core   +1 more source

Diagnostic reproducibility of the elongated styloid process Reprodutibilidade diagnóstica do alongamento do processo estilóide

Journal of Applied Oral Science, 2003
The aim of this study was to estimate the reproducibility related to the presence and to the measurements of elongated styloid process (ESP), based on panoramic radiographs and the prevalence of ESP.
Gulnara Scaf, Deborah Queiroz de Freitas, Leonor de Castro Monteiro Loffredo   +2 more
doaj   +1 more source