Results 91 to 100 of about 11,276 (296)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases [PDF]
, 2018 It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic ...
Rory R. Koenen +4 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Impact on calcification of aortic arch by lifestyle-related, physiologic and biochemical factors [PDF]
, 2009 OBJECTIVE: To explore the impact of lifestyle-related, physiological and biochemical factors on aortic arch calcification (AAC).METHODS: 20 430 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the ...
Liu, Bin +9 more
core
Motor physiotherapy in the treatment of preterm infants with metabolic bone disease [PDF]
, 2011 OBJECTIVE: To review the role of motor physiotherapy in the treatment of preterm infants at risk of developing metabolic bone disease. DATA SOURCES: This is a review of articles published between 1986 and 2009, using the following key-words: premature ...
Luciana Volpiano Fernandes +8 more
core +1 more source
Humoral Bone Morphogenetic Protein 2 Is Sufficient for Inducing Breast Cancer Microcalcification
Molecular Imaging, 2008 Microcalcifications are an important diagnostic marker for breast cancer on mammograms, yet the mechanism of their formation is poorly understood. Indeed, there is presently no short-latency, high-yield, syngeneic rodent model of the process.
Fangbing Liu +9 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Demystifying the Paradox of Biomineralization: Mechanisms Regulating Simultaneous Physiology and Pathologic Bone Formation [PDF]
, 2018 Calcium and phosphate are essential elements in many biological processes, such as basic cellular function and signaling, yet they also combined to make biological crystals, most notably hydroxyapatite found in bone.
Moore-Lotridge, Stephanie Nicole
core
Central role of pyrophosphate in acellular cementum formation.
PLoS ONE, 2012 BackgroundInorganic pyrophosphate (PP(i)) is a physiologic inhibitor of hydroxyapatite mineral precipitation involved in regulating mineralized tissue development and pathologic calcification.
Brian L Foster +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source