Results 141 to 150 of about 221,745 (317)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies [PDF]

, 2017
Carla Caffarelli,1 Andrea Montagnani,2 Ranuccio Nuti,1 Stefano Gonnelli1 1Department of Medicine, Surgery and Neuroscience, University of Siena, Italy; 2Division of Internal Medicine, General Hospital Misericordia, Grosseto, Italy Background ...
Montagnani A, Caffarelli C, Gonnelli S, Nuti R   +3 more
core  

A Case of Intestinal Granular Calcifications Associated With Phosphate Binder Use in a Patient on Hemodialysis

Clinical Case Reports
An experienced physician correctly identified a high‐intensity intestinal X‐ray from Lanthanum Carbonate, preventing unnecessary tests and enabling proper treatment. Awareness of this is vital in managing renal failure patients.
Takaaki Nagao, Yosuke Azuma, Ryo Ichibayashi   +2 more
doaj   +1 more source

Integrated multi-omics analysis reveals key hub genes and mechanisms in calcific aortic stenosis

Frontiers in Cardiovascular Medicine
ObjectiveAortic stenosis (AS) is a critical risk factor for the development of structural heart disease, and identifying its pathogenic genes will provide new insights into cardiac pathology and treatment.Methods“edgeR” was used to calculate ...
Feng-Xia Wang, Shuai Liu, Hao-Qiang Guo, Jia-Qing Yu, Jun Cui, Qi Cheng, Nilupaer Aisikeer, Fen Liu, Ming-Jun Duan, Xiang Xie, Yi-tong Ma, Yi-tong Ma   +11 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Responses of the emiliania huxleyi proteome to ocean acidification [PDF]

Ocean acidification due to rising atmospheric CO2 is expected to affect the physiology of important calcifying marine organisms, but the nature and magnitude of change is yet to be established.
Greaves, Mervyn, O'Connor, David, Jones, Bethan M., Iglesias-Rodriguez, M. Debora, Skipp, Paul J., Edwards, Richard J., Elderfield, Henry   +6 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Shell dissolution rates differ fourfold between mussel species

Royal Society Open Science
Ocean acidification poses a critical threat to marine calcifiers globally and is particularly severe in the California Current System, where ecologically and economically important bivalves experience reduced calcification under climate change.
Rachel R. Carlson, Mazie A. Lewis, Aaron T. Ninokawa, Alisha M. Saley, Tessa M. Hill, Brian Gaylord   +5 more
doaj   +1 more source

Aortic calcification [PDF]

Postgraduate Medical Journal, 1994
M A, al-Kutoubi, L, Kreel
openaire   +2 more sources