Results 131 to 140 of about 245,373 (310)

Integrated multi-omics analysis reveals key hub genes and mechanisms in calcific aortic stenosis

Frontiers in Cardiovascular Medicine
ObjectiveAortic stenosis (AS) is a critical risk factor for the development of structural heart disease, and identifying its pathogenic genes will provide new insights into cardiac pathology and treatment.Methods“edgeR” was used to calculate ...
Feng-Xia Wang, Shuai Liu, Hao-Qiang Guo, Jia-Qing Yu, Jun Cui, Qi Cheng, Nilupaer Aisikeer, Fen Liu, Ming-Jun Duan, Xiang Xie, Yi-tong Ma, Yi-tong Ma   +11 more
doaj   +1 more source

Intramyocardial Calcification with Mitral Annular Calcification

Internal Medicine, 2011
Shiga, Yuhei, Miura, Shin-ichiro, Nakamura, Ayumi, Saku, Keijiro   +3 more
openaire   +3 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Calcification, necrosis and atrophy of normal tissues by calcification techniques [PDF]

, 2010
Se empleó una técnica de calcificación de órganos mediante inyecciones con permanganato de potasio, con o sin administración previa de dihidrotaquisterol. El tejido clasificado pasa posteriormente a tejido fibroso cicatricial.
Martin, Alcides Amílcar, De Carli, Hugo Omar   +1 more
core  

Calcification Patterns in Papillary Thyroid Carcinoma are Associated with Changes in Thyroid Hormones and Coronary Artery Calcification

, 2018
Recent studies suggested that a lower serum thyroid hormone level is associated with more vascular calcification. However, it has been rarely evaluated whether lower thyroid hormone levels affect the calcification of thyroid cancer and there is a ...
Min-Hee Kim, Bong Cha, Jeong-Sun Han, Kwanhoon Jo, Chan Jung, Jeonghoon Ha, Moo Kang, Dong-Jun Lim, Jeongmin Lee   +8 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Calcification, necrosis and atrophy of normal tissues by calcification techniques [PDF]

, 1969
Se empleó una técnica de calcificación de órganos mediante inyecciones con permanganato de potasio, con o sin administración previa de dihidrotaquisterol. El tejido clasificado pasa posteriormente a tejido fibroso cicatricial.
Martin, Alcides Amílcar, De Carli, Hugo Omar   +1 more
core  

Genetics in Arterial Calcification

, 2011
Artery calcification reflects an admixture of factors such as ectopic osteochondral differentiation with primary host pathological conditions. We review how genetic factors, as identified by human genome-wide association studies, and incomplete ...
Frank Rutsch, Yvonne Nitschke, Robert Terkeltaub   +2 more
core   +1 more source

Shell dissolution rates differ fourfold between mussel species

Royal Society Open Science
Ocean acidification poses a critical threat to marine calcifiers globally and is particularly severe in the California Current System, where ecologically and economically important bivalves experience reduced calcification under climate change.
Rachel R. Carlson, Mazie A. Lewis, Aaron T. Ninokawa, Alisha M. Saley, Tessa M. Hill, Brian Gaylord   +5 more
doaj   +1 more source

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source