Results 111 to 120 of about 245,373 (310)

Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm

, 2008
BackgroundIncreased biomechanical stresses within the abdominal aortic aneurysm (AAA) wall contribute to its rupture. Calcification and intraluminal thrombus can be commonly found in AAAs, but the relationship between calcification/intraluminal thrombus ...
U-King-Im, J., Tang, T. Y., Jonathan H. Gillard, See, T. C., Zhi-Yong Li, Tjun Y. Tang, Edmund Soh, Li, Z. Y., Soh, E., Jean U-King-Im, Teik Choon See, Gillard, J. H.   +11 more
core   +1 more source

Impact of calcification on Murray law-based quantitative flow ratio for physiological assessment of intermediate coronary stenoses

Cardiology Journal
BACKGROUND: To investigate the influence of coronary calcification on the diagnostic performance of Murray law-based quantitative flow ratio (μQFR) in identifying hemodynamically significant coronary lesions referenced to fractional flow reserve (FFR ...
Wenjie Zuo, Renhua Sun, Yang Xu, Zhenjun Ji, Rui Zhang, Xiaoguo Zhang, Shengxian Tu, Genshan Ma   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Coronary Calcification and Hormones

, 2011
The pathogenesis of coronary artery calcification and its role in atherogenesis has not been completely understood but is a new focus of interest in experimental and clinical research.
Henein, Michael Y,, Koulaouzidis, George,, George Koulaouzidis, Michael Henein   +3 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Apoptosis and Calcification [PDF]

, 1995
Calcification in necrosis has long been known. Of the tissue components, the cells are most vulnerable. Nevertheless, little attention has been paid to the role of cell death in calcification. This review attempts to update the mechanism of calcification
Kim, Kookmin M.
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Progresses in algal calcification

, 2023
Algal calcification is one of the main forms of biological calcification and an important component of calcification productivity. Calcification is currently known to exist in some species of both microalgae and macroalgae, and involve four sequential ...
刘正一, 孙林, 赵辉, 秦松
core  

Seawater carbonate chemistry and net community calcification, production and respiration of coral reef

, 2020
Previous studies have found that calcification in coral reefs is generally stronger during the day, whereas dissolution is prevalent at night. On the basis of these contrasting patterns, the diel variations of net community calcification (NCC) were ...
Chou, Wen-Chen, Huang, Wei-Jen, Chen, Ying Hsuan, Liu, Pi-Jen   +3 more
core   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source