Results 121 to 130 of about 221,745 (317)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Hepatocellular calcification [PDF]

, 1987
Autopsy of a twenty year old girl dying from complications of renal and cardiac failure demonstrated severe hepatocellular calcification, a rare finding.
Ladefoged, Claus, Frifelt, J J
core   +1 more source

Pulmonary ossification: a case report

Frontiers in Medicine
Pulmonary calcification and ossification are uncommon findings characterized by the deposition of calcium salts or bone tissue in the lung, generally associated with chronic kidney disease, hyperparathyroidism, and several other causes (1).
C. Di Somma, A. Annunziata, A. Coppola, G. E. Polistina, A. Marotta, G. Fiorentino   +5 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Progresses in algal calcification [PDF]

, 2023
Algal calcification is one of the main forms of biological calcification and an important component of calcification productivity. Calcification is currently known to exist in some species of both microalgae and macroalgae, and involve four sequential ...
刘正一, 孙林, 赵辉, 秦松
core  

Aragonite Saturation State as an Indicator for Oyster Habitat Health in the Delaware Inland Bays

Coasts
Bivalves such as oysters rely on aragonite and calcite for shell formation via the biomineralization of calcium carbonate. Ocean acidification reduces carbonate ion availability, compromising shell growth and inducing dissolution under undersaturated ...
Tahera Attarwala, Amin Boukari, Gulnihal Ozbay   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Macrophages as key modulators of calcific aortic valve disease

Frontiers in Cardiovascular Medicine
Calcific aortic valve disease (CAVD), defined by thickening, fibrosis, and mineralization of the aortic valve (AV) leaflets, is the most common valvular heart disease worldwide.
Nervana Issa, Gérémy Blot, Alexandre Candellier, Cédric Boudot, Loïc Louvet, Saïd Kamel, Saïd Kamel, Youssef Bennis, Youssef Bennis, Lucie Hénaut   +9 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Impact of calcification on Murray law-based quantitative flow ratio for physiological assessment of intermediate coronary stenoses

Cardiology Journal
BACKGROUND: To investigate the influence of coronary calcification on the diagnostic performance of Murray law-based quantitative flow ratio (μQFR) in identifying hemodynamically significant coronary lesions referenced to fractional flow reserve (FFR ...
Wenjie Zuo, Renhua Sun, Yang Xu, Zhenjun Ji, Rui Zhang, Xiaoguo Zhang, Shengxian Tu, Genshan Ma   +7 more
doaj   +1 more source