Results 91 to 100 of about 245,373 (310)
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
BiomoleculesBackground: Brain calcifications, found in various conditions, may be incidental or crucial for diagnosis. They occur in physiological changes, infections, genetic diseases, neurodegenerative conditions, vascular syndromes, metabolic disorders, endocrine
Alexandru Garaba +8 more
doaj +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Deciphering Ectopic Calcification: Contribution of the Rare, Inherited Disorder Pseudoxanthoma Elasticum [PDF]
, 2015 Soft connective tissue calcification is still an intriguing problem due to the high number of genes, proteins, and enzymes involved in the process. Numerous epidemiological and experimental studies of the ectopic calcification associated with metabolic ...
Ivonne Pasquali Ronchetti
core
Proposed pathogenesis of peritoneal calcification.
, 2013 Unphysiologic dialysate and peritonitis episodes stimulate mesothelial cells which secret calcification inhibitors (matrix Gla protein, MGP) and other cytokines.
Chung-Yi Yang (343307) +11 more
core +1 more source
Frontiers in Marine ScienceStony corals possess major components of the circadian system, which oscillate in response to light-dark cycles in aquatic environments. However, the extent to which the circadian system influences physiological processes remains unknown.
Zongyan Shi, Akihiro Takemura
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Encephalopathies with intracranial calcification in children: clinical and genetic characterization
, 2018 Background We present a group of patients affected by a paediatric onset genetic encephalopathy with cerebral calcification of unknown aetiology studied with Next Generation Sequencing (NGS) genetic analyses.
Simona Orcesi +14 more
core +1 more source
Osseous Metaplasia in Uterine Leiomyoma: A Case Report
Journal of Clinical and Diagnostic ResearchThe leiomyoma uteri is one of the most common tumours of the female genital tract. It is more common in women above 50 years and is known to shrink in size after menopause.
Pawni Prabhat +2 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source