Results 71 to 80 of about 245,373 (310)

Clinical value of calcification afterneoadjuvant chemotherapy in breast cancer

肿瘤影像学, 2020
Objective: To investigate the relationship between the change of microcalcification and tumor pathological response after neoadjuvant chemotherapy in breast cancer.
ZHAO Huijuan, LIU Xiangyu, YIN Chengfang
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characteristics and prognostic values of abdominal aortic branches calcification in hemodialysis patients

Renal Failure
Background Vascular calcification is highly prevalent and associated with mortality in hemodialysis patients. However, extreme splanchnic arterial calcification in calciphylaxis with poor prognosis raises questions regarding the reliability of previous ...
Wen Shi, Xiaotong Xie, Yu Zhao, Yuqiu Liu, Xiaoliang Zhang   +4 more
doaj   +1 more source

Ontogeny of respiration and feeding structures of skull in Persian sturgeon, Acipenser persicus (Bordin, 1897) [PDF]

بوم‌شناسی آبزیان, 2016
In the present study, the process of the skull development and calcification in Persian sturgeon (Acipenser persicus) was studied. Development of cartilage started after hatching around the head and notochord (10.6 mm, total length, TL) and the first ...
Hamid Eshaghzadeh, Arash Akbarzadeh, Mahtab Yarmohammadi, Enric Gisbert   +3 more
doaj  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Calcification rates of station TT011_12-TM95

, 2003
Calcification rates of station TT011_7 ...
William M Balch (6978683), Balch, William M   +1 more
core   +1 more source

Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study

BMC Neurology
Background Calcification is common in advanced atheromatous plaque, but its clinical significance remains unclear. This study aimed to assess the prevalence of plaque calcification in the moderate-to-severe internal carotid artery stenosis and ...
Fengli Fu, Xiaoli Liu, Rui Zhang, Siran Zhang, Jianhua Mao, Yan Li, Shu Wan, Shanhu Xu   +7 more
doaj   +1 more source

Ultrastructural Aspects of Physiological Mineralization: A Comparative Study in Different Hard Tissues

Biomolecules
The calcified tissues of vertebrates are essentially represented by bone, cartilage, dentin and calcified tendons. In all these tissues a major hallmark of mineralization is the deposition of the inorganic phase on a pre-existing collagen template, but ...
Marina Borgese, Mario Raspanti, Marina Protasoni, Piero Antonio Zecca, Fulvia Ortolani, Marcella Reguzzoni   +5 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Limited Cross-Shelf Variation in the Growth of Three Branching Corals on Australia’s Great Barrier Reef

Diversity, 2018
Pronounced differences exist in the biodiversity and structure of coral reef assemblages with increasing distance from shore, which may be expected given marked cross-shelf gradients in environmental conditions.
Deborah Burn, Morgan S. Pratchett, Scott F. Heron, Cassandra A. Thompson, Deborah J. Pratchett, Andrew S. Hoey   +5 more
doaj   +1 more source