Results 51 to 60 of about 407,718 (365)

Socioeconomic Status and Subclinical Coronary Disease in the Whitehall II Epidemiological Study

, 2010
Background: There are pronounced socioeconomic disparities in coronary heart disease, but the extent to which these primarily reflect gradients in underlying coronary artery disease severity or in the clinical manifestation of advanced disease is ...
Andrew Steptoe, Katie O'Donnell, Mark Hamer, Hamer, M, Lahiri, A, Steptoe, A, Marmot, MG, O'Donnell, K, Michael G Marmot, Venuraju, S, Avijit Lahiri, Michael G. Marmot, Shreenidhi Venuraju   +12 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance.

Journal of the American Society of Nephrology, 2019
BACKGROUND Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) have been associated with cardiovascular morbidity and mortality in patients with CKD.
B. Opdebeeck, Stuart Maudsley, A. Azmi, Annelies De Maré, Wout De Leger, B. Meijers, A. Verhulst, P. Evenepoel, P. D'Haese, E. Neven   +9 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Evidence of bacterial imprints in different types of non-struvite kidney stones

BMC Urology
Background Recent studies of renal lithiasis identified bacterial imprints in apatite phosphate stones and mixed calcium oxalate/apatite phosphate stones, neither of which contained struvite.
Felix Grases, Antonia Costa-Bauzá, Francesca Julià, Bernat Isern, Jordi Guimerà, José Luis Bauzá-Quetglas, Valentí Tubau, Enrique Pieras   +7 more
doaj   +1 more source

Probiotic Supplementation in Chronic Kidney Disease: Outcomes on Uremic Toxins, Inflammation, and Vascular Calcification from Experimental and Clinical Models

Toxins
Chronic kidney disease (CKD) is associated with gut microbiota alterations that contribute to increased inflammation and the generation of uremic toxins and may worsen the disease progression.
Teresa Obrero, María Victoria Pendón-Ruiz de Mier, Jose E. Gordillo-Arnaud, María José Jiménez Moral, Victoria Vidal, Fátima Guerrero, Andrés Carmona, María Encarnación Rodríguez-Ortiz, Ana Isabel Torralbo, Raquel Ojeda, Cayetana Moyano, Mercedes Sanchez-Ramade, Juan Mesa, Daniel J. López-Ruiz, Karen Valdés-Díaz, Raquel María García-Sáez, Daniel Jurado-Montoya, Cristian Rodelo-Haad, María Álvarez-Benito, Griet Glorieux, Mariano Rodríguez, Sagrario Soriano-Cabrera, Juan Rafael Muñoz-Castañeda   +22 more
doaj   +1 more source

Circulating microRNAs and vascular calcification in hemodialysis patients

Journal of International Medical Research, 2019
Objective Vascular calcification is common in chronic dialysis patients and is associated with increased morbidity and mortality. However, the role of circulating microRNAs (miRs) in vascular calcification has rarely been investigated.
Chien-Te Lee, Yueh-Ting Lee, You-Lin Tain, Hwee-Yeong Ng, Wei-Hung Kuo   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Metastatic calcification

Dermatology Online Journal, 2003
Calciphylaxis is a rare, painful, and debilitating disease of widespread metastatic calcification that progresses to ischemic tissue necrosis. It occurs almost exclusively in patients with end-stage renal disease and secondary hyperparathyroidism. Reticulated, violaceous, mottled patches commonly appear on the lower extremities and progress to cordlike
openaire   +4 more sources

Calcific Myonecrosis

acta orthopaedica et traumatologica turcica, 2008
Calcific myonecrosis is a rare complication of limb trauma, that may occur after many years. It is characterized by dystrophic calcification that develops in the late period following compartment syndrome usually in the lower limb. We present a 66-year-old man who developed calcific myonecrosis 35 years after surgical intervention for compartment ...
Melih, Güven, Murat, Cakar, Ibrahim, Başsorgun, Bariş, Kadioğlu, Volkan, Kilinçoğlu, Abdullah, Eren   +5 more
openaire   +2 more sources