Results 121 to 130 of about 2,232 (157)
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Applied Microbiology and Biotechnology, 2013
The five-membered aromatic nitrogen heterocyclic pyrrole ring is a building block for a wide variety of natural products. Aiming at generating new pyrrole-containing derivatives as well as to identify new candidates that may be of value in designing new anticancer, antiviral, and/or antimicrobial agents, we employed a strategy on pyrrole-containing ...
Shuangjun Lin +2 more
exaly +3 more sources
The five-membered aromatic nitrogen heterocyclic pyrrole ring is a building block for a wide variety of natural products. Aiming at generating new pyrrole-containing derivatives as well as to identify new candidates that may be of value in designing new anticancer, antiviral, and/or antimicrobial agents, we employed a strategy on pyrrole-containing ...
Shuangjun Lin +2 more
exaly +3 more sources
Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882 [PDF]
Applied and Environmental Microbiology, 2018 © 2018 American Society for Microbiology. Calcimycin, N-demethyl calcimycin, and cezomycin are polyether divalent cation ionophore secondary metabolites produced by Streptomyces chartreusis.
Jingdan Liang +2 more
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SYNTHETIC STUDIES TOWARDS CALCIMYCIN [PDF]
, 1981 P.A. Grieco, E. Williams, Ken-ichi Kanai
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Totalsynthese von Calcimycin [PDF]
Nachrichten aus Chemie, Technik und Laboratorium, 1982 openaire +2 more sources
S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells [PDF]
Molecular Biology of the Cell, 2011 The calcium-binding protein S100A4 is a central mediator of metastasis formation in colon cancer. S100A4 is a target gene of the Wnt/β-catenin pathway, which is constitutively active in the majority of colon cancers.
Ulrike Sack +2 more
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Mode d'action de la calcimycine (A. 23187)
Journal de Chimie Physique, 1979Dans le cadre d’une etude generale du mode d’action des antibiotiques ionophores carboxyliques, on etudie, par une methode potentiometrique les equilibres, dans le methanol, de la calcimycine avec les ions alcalins et alcalinoterreux. Pour ces derniers, on montre l’existence de deux types de complexes de stœchiometrie 1 : 1 et 1 : 2.
Claude Tissier +3 more
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Synthesis of a biomimetic model of calcimycin (A 23187) with a demethylated skeleton
Tetrahedron Letters, 1989Abstract A demethylated model ( 15 ) of Calcimycin ( 1 ) has been synthesized from the known 2,8-dibromo-1,7 dioxaspiro (5.5) undecane ( 6 ) ; biphasic extraction experiments indicated a net decrease of affinity towards Mg++ and Ca++ for ( 15 ) versus ( 1 ).
Jean-Gabriel Gourcy +3 more
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ChemInform Abstract: STEREOCONTROLLED TOTAL SYNTHESIS OF ANTIBIOTIC A‐23187 (CALCIMYCIN)
Chemischer Informationsdienst, 1982AbstractDer ausgehend vom Keton (I) zugängliche Alkohol (Va) wird durch Oxidation und Grignardreaktion zu einem trennbaren Gemisch der Vinylderivate (Vb) + (Vc) umgesetzt, die sich beide in mehreren Stufen in den Ester (VIa) bzw. dessen Folgeprodukt (VIb) überfüh; ren lassen.
G. R. MARTINEZ +4 more
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Total synthesis of antibiotic A23187 (calcimycin) from D-glucose
Tetrahedron, 1986Abstract The fully stereocontrolled synthesis of A23187 by using the chirons derived from D-glucose is described.
Yoshiaki Nakahara +3 more
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