Results 131 to 140 of about 2,749 (172)

Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner

Biochimica Et Biophysica Acta - General Subjects, 2017
Phenotypic screening led to the identification of calcimycin as a potent inhibitor of Mycobacterium bovis BCG (M. bovis BCG) growth in vitro and in THP-1 cells. In the present study, we aim to decipher the mechanism of antimycobacterial activity of calcimycin. We noticed that treatment with calcimycin led to up-regulation of different autophagy markers
Shradha Mawatwal, Assirbad Behura, Abhirupa Ghosh   +2 more
exaly   +3 more sources

Modifications of benzoxazole ring substituents in A. 23187 (calcimycin). Effect on cation carrier properties.

Journal of Inclusion Phenomena, 1987
Introduction. Calcimycin (or A.23187) belongs to the growing family of bacterial carboxylic polyether ionophores(1).It was isolated from a strain of Streptomyces Chartreusis NRRL 3882 (2).
M. Prudhomme, G. Dauphin, J. Guyot, G. Jeminet, N. Gresh   +4 more
exaly   +2 more sources

Elaboration of the C(3)-C(12) carbon fragment of calcimycin (A-23187). Formal total synthesis of calcimycin

Journal of Organic Chemistry, 1980
Paul A. Grieco, Eric Williams, Hideo Tanaka, Sydney Gilman   +3 more
exaly   +2 more sources

Ionophores: Calcimycin

2011
exaly   +2 more sources

Mode of action of calcimycin (A23187)

Journal de Chimie Physique, 1997
Les constantes de formation des complexes et des complexes basiques de la calcimycine avec les cations lanthane, gadolinium et europium (III) sont obtenus dans le methanol par une methode potentiometrique. L'analyse des spectres RPE du gadolinium pour des concentrations variables en calcimycine, perchlorate de gadolinium et methoxyde de ...
A Ouahabi, M Tissier, Y Pointud, G Jeminet, J Juillard   +4 more
openaire   +1 more source

Mode d'action de la calcimycine (A. 23187)

Journal de Chimie Physique, 1979
Dans le cadre d’une etude generale du mode d’action des antibiotiques ionophores carboxyliques, on etudie, par une methode potentiometrique les equilibres, dans le methanol, de la calcimycine avec les ions alcalins et alcalinoterreux. Pour ces derniers, on montre l’existence de deux types de complexes de stœchiometrie 1 : 1 et 1 : 2.
Claude Tissier, Jean Juillard, Michel Dupin, Georges Jeminet   +3 more
openaire   +1 more source

ChemInform Abstract: ELABORATION OF THE C(3)‐C(12) CARBON FRAGMENT OF CALCIMYCIN (A‐23187). FORMAL TOTAL SYNTHESIS OF CALCIMYCIN

Chemischer Informationsdienst, 1980
AbstractAus dem Bicyclo[2,2, 1] heptenon (I) erhält man bei der Behandlung mit alkalischem Wasserstoffperoxid das Lacton (II), das über angedeutete Zwischenstufen wie (IIIa) und (IV) das definierte Diol (V) und weiter das Ketal (VI) liefert.
P. A. GRIECO, E. WILLIAMS, H. TANAKA, S. GILMAN   +3 more
openaire   +1 more source

ChemInform Abstract: Synthetic Studies on Antibiotic A23187 (Calcimycin).

Chemischer Informationsdienst, 1984
AbstractAus dem Glucosid (I) sind die optisch aktiven Synthesebausteine (II) und (III) zugänglich, die zusammen mit dem Aminophenol (IV) als Bausteine für die Synthese von Calcimycin (V) verwendet werden.
Y. NAKAHARA, A. FUJITA, T. OGAWA
openaire   +1 more source

Total Synthesis of Antibiotic A23187 (Calcimycin) from D-Glucose: Communication

Journal of Carbohydrate Chemistry, 1984
Abstract Antibiotic A23187 1 is a cation ionophore highly specific for Ca2+. Because of its unique dioxaspiro ring structure as well as its biological activities,2 several synthetic approaches to the compound have been reported.3 We report here the first example of the total synthesis of based on the use of a carbohydrate template.4 The target ...
Yoshiaki Nakahara, Akira Fujita, Tomoya Ogawa   +2 more
openaire   +1 more source

Total synthesis of antibiotic A23187 (calcimycin) from D-glucose

Tetrahedron, 1986
Abstract The fully stereocontrolled synthesis of A23187 by using the chirons derived from D-glucose is described.
Yoshiaki Nakahara, Akira Fujita, Kazuo Beppu, Tomoya Ogawa   +3 more
openaire   +1 more source