Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, EarlyView.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Evidence of Calcitonin-Induced Inhibition of Calcitonin Secretion in Porcine Thyroid Slices [PDF]
, 1976 A. L. Orme, J. Thomas Pento
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Continuous growth of proximal tubular kidney epithelial cells in hormone-supplemented serum-free medium. [PDF]
, 1982 An epithelial cell line from pig kidney (LLC-PK1) with properties of proximal tubular cells can be maintained indefinitely in hormone-supplemented serum-free medium. Continuous growth requires the presence of seven factors: transferrin, insulin, selenium,
Chuman, L +3 more
core
Can serum neuropeptide levels help diagnose pediatric migraine? A prospective case–control study
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective The objective of this study was to examine the serum levels of vasoactive neuropeptides (calcitonin gene‐related peptide [CGRP], pituitary adenylate cyclase‐activating peptide‐38 [PACAP‐38], substance P [SP], and vasoactive intestinal peptide [VIP], which have been linked to the pathophysiology of migraine in adults) in pediatric ...
Sibğatullah Ali Orak +8 more
wiley +1 more source
Distribution of Calcitonin-Containing Cells in the Normal Neonatal Human Thyroid Gland: A Correlation of Morphology with Peptide Content [PDF]
, 1975 Hubert J. Wolfe +3 more
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A critical structured review of economic evaluations of interventions for the prevention and treatment of osteoporosis [PDF]
Osteoporosis is a major cause of morbidity, mortality and resource cost amongst the elderly population. Hip fracture is the most serious of the osteoporotic fractures, with approximately 10-20% of patients dying within six months of sustaining a fracture.
Bernie O'Brien +3 more
core
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To assess whether glucagon‐like‐peptide‐1 receptor (GLP‐1R) agonists could serve as a novel prophylactic treatment for migraine in patients with obesity. Background Increased intracranial pressure (ICP) is speculated to play a role in migraine mechanisms, as chronic migraine and idiopathic intracranial hypertension without ...
Simone Braca +6 more
wiley +1 more source
European Thyroid JournalObjective: At present, total thyroidectomy and central neck dissection are the surgical approaches recommended for the initial treatment of medullary thyroid cancer (MTC) independently of the size, number of tumor foci, age of patients, and other ...
Cappagli Virginia +10 more
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Acute and Chronic Fluctuations of Immunoreactive and Biologically Active Plasma Calcitonin in the Rat* [PDF]
, 1978 Bernard A. Roos +3 more
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Headache: The Journal of Head and Face Pain, EarlyView.Plain Language Summary: This randomized trial was designed to test the effectiveness and safety of rimegepant for the acute treatment of migraine among adults in Japan. Results indicated that rimegepant was more effective than placebo, and the 75 mg dose was observed to be more effective than the 25 mg dose.
Koichi Ikeda +11 more
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