Results 91 to 100 of about 49,400 (296)

Histone H3 Lysine 9 Acetylation is Downregulated in GDM Placentas and Calcitriol Supplementation Enhanced This Effect

International Journal of Molecular Sciences, 2018
Despite the ever-rising incidence of Gestational Diabetes Mellitus (GDM) and its implications for long-term health of mothers and offspring, the underlying molecular mechanisms remain to be elucidated.
Paula Hepp, S. Hutter, J. Knabl, S. Hofmann, C. Kuhn, S. Mahner, U. Jeschke   +6 more
semanticscholar   +1 more source

Effect of vitamin D3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin D deficiency [PDF]

, 2015
Background: Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life.
Fatahi, N., Mohammadian, S., Vakili, M.A., Zaeri, H.   +3 more
core   +1 more source

Aetiological relevance of haematological, biochemical and endocrine parameters on equine odontoclastic tooth resorption and hypercementosis (EOTRH)

Equine Veterinary Journal, EarlyView.
Abstract Background The dental syndrome EOTRH is a painful, progressive dental disease with an unknown aetiology. The often painful nature of EOTRH emphasises the need for a better knowledge of the underlying pathogenic mechanism and risk factors. A comparative analysis of haematological, biochemical and endocrine values in EOTRH‐affected and non ...
Melusine Tretow, Anna M. Hain, Astrid Bienert‐Zeit   +2 more
wiley   +1 more source

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells

Drug Metabolism And Disposition, 2018
Efflux transporters P-glycoprotein (P-gp/ABCB1), multidrug resistance protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) can affect the efficacy and toxicity of a wide variety of drugs and are implicated in multidrug resistance ...
Kee W. Tan, A. Sampson, Bremansu Osa-Andrews, S. Iram   +3 more
semanticscholar   +1 more source

Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes

Journal of Biomedical Science, 2018
Background Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1).
Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao, Yi-Jen Chen   +4 more
doaj   +1 more source

Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study.

American Journal of Kidney Diseases, 2018
RATIONALE & OBJECTIVES Lower 25-hydroxyvitamin D concentrations have been associated with risk for kidney function decline, heart failure, and mortality.
U. Selamet, R. Katz, C. Ginsberg, D. Rifkin, L. Fried, S. Kritchevsky, A. Hoofnagle, Kirsten Bibbins-Domingo, David A. Drew, T. Harris, A. Newman, O. Gutiérrez, M. Sarnak, M. Shlipak, J. Ix   +14 more
semanticscholar   +1 more source

Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study. [PDF]

, 2015
BACKGROUND: Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA).
Barchetta, Ilaria, Cavallo, Maria Gisella, Ceccarelli, Fulvia, DI FRANCO, Manuela, Frisenda, S, Gerardi, Mc, Iannuccelli, Cristina, Valesini, Guido   +7 more
core   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, EarlyView.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

Beilstein Journal of Nanotechnology, 2015
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on ...
Maria J. Ramalho, Joana A. Loureiro, Bárbara Gomes, Manuela F. Frasco, Manuel A. N. Coelho, M. Carmo Pereira   +5 more
doaj   +1 more source

Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor-positive, human epidermal growth factor receptor 2-positive breast cancer cells

Molecular Medicine Reports, 2018
The Janus kinase (JAK)1 and JAK2 inhibitor, ruxolitinib, and the active form of vitamin D (calcitriol) were previously reported to possess anticancer effects in breast cancer.
S. Lim, Y. Jeon, Hongki Gwak, S. Y. Kim, Y. Suh   +4 more
semanticscholar   +1 more source