Results 71 to 80 of about 25,694 (210)

The biological action of calcitriol in renal failure

, 1994
Abnormal calcitriol [1,25(OH)2 vitamin D] metabolism plays a major role in the pathophysiology of renal osteodystrophy and other alterations of mineral metabolism associated with chronic renal failure. Growing knowledge of the protean biologic actions of
HSU, C, Vanholder, Raymond, YOUNG, E, Young, Eric W., Patel, Sanjeevkumar R., PATEL, S, Hsu, Chen H.   +6 more
core   +1 more source

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

Beilstein Journal of Nanotechnology, 2015
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on ...
Maria J. Ramalho, Joana A. Loureiro, Bárbara Gomes, Manuela F. Frasco, Manuel A. N. Coelho, M. Carmo Pereira   +5 more
doaj   +1 more source

Microstructural Evidence for Early Childhood Stress in a Community in Transition at Hisban, Jordan

American Journal of Biological Anthropology, Volume 190, Issue 2, June 2026.
ABSTRACT Objectives Identification of stress across infancy and childhood can reflect maternal and environmental influences on early life health. In the 19th century community of Hisban, many infants died before 2 years of age with evidence of metabolic disease, including rickets, that likely ties with maternal health.
Kristina Cockerille, Akacia Propst, Bonnie Kahlon, Daniel Temple, Megan Perry   +4 more
wiley   +1 more source

Subfractions in uremic plasma ultrafiltrate inhibit calcitriol metabolism

, 1973
Subfractions in uremic plasma ultrafiltrate inhibit calcitriol metabolism. Previous study from our laboratory has demonstrated that uremic plasma ultrafiltrate suppresses both the production rate (PR) and metabolic clearance rate (MCR) of calcitriol in ...
Vanholder, Raymond, De Smet, Rita R., Patel, Sanjeev, Sandra, Patrick, Ringoir, Severin M.G., Hsu, Chen H.   +5 more
core   +2 more sources

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

PLGA nanoparticles for calcitriol delivery

, 2015
Calcitriol, the active metabolite of Vitamin D-3, is a potential anticancer agent but exhibits several drawbacks. Therefore, new therapeutic strategies, as specific drug delivery systems, must be developed in order to overcome those limitations.
M F Frasco, M A N Coelho, M. F. Frasco, M. A. N. Coelho, B Gomes, M C Pereira, M. J. Ramalho, J A Loureiro, B. Gomes, M. C. Pereira, M J Ramalho, J. A. Loureiro   +11 more
core   +1 more source

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 745-755, June 2026.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - preliminary study results

BMC Microbiology
Background Aerobic vaginitis (AV) is a state of abnormal vaginal microbiota, which is associated with increased numbers of aerobic, enteric bacteria and inflammation of the vaginal epithelium.
Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus   +3 more
doaj   +1 more source

Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2019
The anticancer activity of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 or calcitriol) has been widely reported in preclinical models. However, systematic investigation into the chemopreventive potential of calcitriol against the spectrum of oral carcinogenesis
Vui King Vincent-Chong, Hendrik DeJong, Kristopher Attwood, Pamela A. Hershberger, Mukund Seshadri   +4 more
doaj   +1 more source

Calcitriol [PDF]

Reactions Weekly, 2019
  +6 more sources