Results 91 to 100 of about 25,694 (210)

Effect of exogenous calcitriol on myopia development and axial length in guinea pigs with form deprivation myopia

open access: yesScientific Reports
The annual increase in myopia prevalence poses a significant economic and health challenge. Our study investigated the effect of calcitriol role in myopia by inducing the condition in guinea pigs through form deprivation for four weeks.
Rongbin Liang   +6 more
doaj   +1 more source

Mitigation of Cisplatin‐Induced Neurotoxicity via Nrf2/HO‐1 Signaling and Autophagy: The Protective Role of Vitamin D

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study investigates the neuroprotective effect of vitamin D against cisplatin‐induced mitochondrial damage and oxidative stress (ROS). HO‐1 expression is increased by vitamin D, which triggers Nrf2 activation and nuclear translocation. The results demonstrate that vitamin D protects brain tissue by strengthening the antioxidant defense system ...
Songul Cuglan   +2 more
wiley   +1 more source

Effect of oral calcium loading on intact PTH and calcitriol in idiopathic renal calcium stone formers and healthy controls [PDF]

open access: yes, 1995
The calciuric response after an oral calcium load (1000 mg elemental calcium together with a standard breakfast) was studied in 13 healthy male controls and 21 recurrent idiopathic renal calcium stone formers, 12 with hypercalciuria (UCa x V > 7.50 mmol ...
Jaeger, P   +5 more
core   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody   +4 more
wiley   +1 more source

Calcitriol corrects bone loss induced by oophorectomy in rats

open access: yes, 1986
The effects of calcitriol on histomorphometric parameters of bone structure, formation, and resorption were evaluated in 21 normal or oophorectomized rats. Twelve rats were oophorectomized; six of these received daily subcutaneous injections of 135 pmol
H. H. Malluche   +3 more
core   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

open access: yesMedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi   +2 more
wiley   +1 more source

Circadian Clock Regulates Epidermal Endocrine System in Homeostatic Skin Pigmentation

open access: yesExperimental Dermatology, Volume 35, Issue 6, June 2026.
ABSTRACT The circadian clock regulates multiple physiological processes in the skin, including local hormone synthesis and pigmentation. However, how circadian regulation interacts with epidermal endocrine signalling in melanocytes remains unclear.
Anya Zhu   +5 more
wiley   +1 more source

Suplementasi Calcitriol Menurunkan Risiko Osteoporosis Tikus Ovariektomi

open access: yes, 2017
Suplemen calcitriol memicu pembentukan tulang, namun juga meningkatkan resorpsi tulang. Penelitian ini dilakukan untuk mengkaji efektivitas calcitriol dalam menurunkan risiko osteoporosis tikus ovariektomi.
., Hartiningsih, Anggraeni, Devita
core   +1 more source

Production and degradation of calcitriol in renal failure rats

open access: yes, 1987
We studied the metabolism of calcitriol in renal failure achieved by nephrectomy in three groups of rats. Group 1 (n = 7) had sham operation of nephrectomy. Group 2 (n = 8) had unilateral nephrectomy. Group 3 (n = 7) had 5/6 nephrectomy.
R. U. Simpson   +3 more
core   +1 more source

Dietary supplementation with calcitriol or quercetin improved eggshell and bone quality by modulating calcium metabolism

open access: yesAnimal Nutrition
This study was aimed to investigate the effects of dietary calcitriol or quercetin supplementation on eggshell and bone quality of laying hens. In trial 1, 72 Hy-Line Brown layers (80-week-old) with weak-shelled strength (25 to 30 N) were assigned into 4
Yu Fu   +7 more
doaj   +1 more source

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