Results 81 to 90 of about 27,436 (194)

Supraphysiological 25‐Hydroxyvitamin D3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Supraphysiological 25(OH)D3 and calcipotriol induced ROS accumulation or redox disturbance, increased mitochondrial membrane depolarization, reduced antioxidant enzyme activity, and caused apoptotic cell death in HeLa cells. ABSTRACT Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies ...
Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Tahir S. Pillay, Rivak Punchoo   +5 more
wiley   +1 more source

Balanced calcitriol treatment to make children grow [PDF]

, 2007
Short stature is an important clinical problem in children with chronic kidney disease. Calcitriol is used as standard therapy to control secondary hyperparathyroidism, but its effect on linear growth remains controversial. Sanchez and He report multiple
Neven, Ellen, Persy, V., D'Haese, P.C., d' Haese, Patrick C., Persy, Veerle, Neven, E.   +5 more
core   +1 more source

CYP24A1 Inhibition Enhances the Antitumor Activity of Calcitriol

, 2010
High systemic exposures to calcitriol are necessary for optimal antitumor effects. Human prostate cancer PC3 cells are insensitive to calcitriol treatment.
Kristie L. Engler, Rui-Xian Kong, Wei-Dong Yu, Donald L. Trump, Candace S. Johnson, Yingyu Ma, Josephia R. Muindi   +6 more
core   +1 more source

Patterns of Osteoporosis Treatment Initiation Following Low‐Trauma Fracture: A Population‐Based Retrospective Cohort Study in New South Wales, Australia, Using Linked Administrative Health Data

Medical Journal of Australia, Volume 224, Issue 9, September 2026.
ABSTRACT Objectives To characterise osteoporosis medicine prescribing patterns following low‐trauma fractures and identify predictors of early treatment initiation. Study Type Retrospective population‐based cohort study. Setting New South Wales, Australia, using statewide linked administrative health data.
Mike Lin, Huy Nguyen, Thach Tran, Robert D. Blank, Dana Bliuc, Jacqueline R. Center   +5 more
wiley   +1 more source

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

Redox Biology, 2019
Purpose: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis.
Yiqin Dai, Jing Zhang, Jun Xiang, Yue Li, Dan Wu, Jianjiang Xu   +5 more
doaj   +1 more source

Experimental Approach for Drug Profiling of Calcitriol in Yeast

, 2016
Vitamin D regulation is associated with several human disorders and contributes to various cellular mechanisms. Calcitriol (commercially available as Rocaltrol), an active Vitamin D metabolite, is known as a neuro-protective and anti-cancer drug but most
Jagadeesan, Sasi Kumar
core   +2 more sources

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

Beilstein Journal of Nanotechnology, 2015
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on ...
Maria J. Ramalho, Joana A. Loureiro, Bárbara Gomes, Manuela F. Frasco, Manuel A. N. Coelho, M. Carmo Pereira   +5 more
doaj   +1 more source

In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - preliminary study results

BMC Microbiology
Background Aerobic vaginitis (AV) is a state of abnormal vaginal microbiota, which is associated with increased numbers of aerobic, enteric bacteria and inflammation of the vaginal epithelium.
Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus   +3 more
doaj   +1 more source

Comment on ‘A Clinically Aligned Two‐Stage Machine Learning Framework for Predicting Hungry Bone Syndrome After Parathyroidectomy’

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Aman Batool Hashmi, Maliha Khalil, Syeda Bareera   +2 more
wiley   +1 more source

Calcitriol implications on human rhabdomyosarcoma: An unexplored field

This work is an extension of our published article in 2022 (https://doi.org/10.1016/j.jsbmb.2022.106146), where we further discuss any recentupdates in this research and analyse the issues addressed in the focal article.Calcitriol, the active form of ...
Irazoqui, Ana Paula, Buitrago, Claudia Graciela   +1 more
core   +1 more source