Results 1 to 10 of about 1,831,077 (313)
Cell Death Discovery, 2021 A Correction to this paper has been published: https://doi.org/10.1038/s41420-021-00445 ...
Farai C. Gombedza +3 more
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Advances in Nutrition, 2011 Calcium is the fifth most abundant element in the body with >99% residing in the skeleton as hydroxyapatite, a complex calcium phosphate molecule. This mineral supplies the strength to bones that support locomotion, but it also serves as a reservoir to maintain serum calcium concentrations.
Connie M Weaver, Munro Peacock
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Development and characterization of a monoclonal antibody blocking human TRPM4 channel
Scientific Reports, 2021 TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4.
See Wee Low +5 more
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Scientific Reports, 2021 Excessive salt intake has been associated with the development of non-communicable diseases, including hypertension with several cardiovascular consequences.
Wacharaporn Tiyasatkulkovit +9 more
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Calcium-induced calcium release [PDF]
Current Biology, 2003 Why is calcium so important? Intracellular calcium controls a diverse array of cellular processes from fertilisation through gene transcription, muscle contraction to cell death. Changes in calcium levels can occur in microseconds or hours, they can be microscopic or propagate throughout cells and tissues.How are calcium levels increased within cells ...
Martin D. Bootman +2 more
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Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis
Scientific Reports, 2023 Clinical studies and structural analyses of salivary stones strongly suggest a linkage between higher saliva calcium (Ca2+) and salivary stone formation, sialolithiasis; however, the process and the mechanism leading to Ca2+ overload during ...
Bok-Eum Choi +4 more
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Scientific Reports, 2023 Iron overload negatively affects bone mass and strength. However, the impact of iron excess on osteocytes—important bone cells for mechanotransduction and remodeling—is poorly understood.
Wasutorn Chankamngoen +6 more
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Scientific Reports, 2021 Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper +5 more
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TRPM4 Blocking Antibody Protects Cerebral Vasculature in Delayed Stroke Reperfusion
Biomedicines, 2023 Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury.
Bo Chen +6 more
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Frontiers in Cell and Developmental Biology, 2020 In stroke and other neurological diseases, Transient Receptor Potential Melastatin 4 (TRPM4) has been reported to cause oncotic cell death which is due to an excessive influx of sodium ions.
Shunhui Wei +8 more
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