Results 1 to 10 of about 1,868,094 (311)

Uncovering Aberrant Mutant PKA Function with Flow Cytometric FRET

Cell Reports, 2016
Biology has been revolutionized by tools that allow the detection and characterization of protein-protein interactions (PPIs). Förster resonance energy transfer (FRET)-based methods have become particularly attractive as they allow quantitative studies ...
Shin-Rong Lee, Lingjie Sang, David T. Yue   +2 more
doaj   +1 more source

Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling

iScience
Summary: One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis are unclear.
Danielle M.A. Ratsma, Max Muller, Marijke Koedam, Johannes P.T.M. van Leeuwen, M. Carola Zillikens, Bram C.J. van der Eerden   +5 more
doaj   +1 more source

S100 Proteins—Intracellular and Extracellular Function in Norm and Pathology

Biomolecules
The S100 proteins are small, ubiquitous, mostly homodimeric proteins containing two EF-hand structures, that is, helix-loop-helix motifs specialized in high-affinity calcium-binding (~10−6 M) [...]
Wiesława Leśniak, Anna Filipek
doaj   +1 more source

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Cell Death and Disease
Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM progression ...
Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván, Judit Herreros   +8 more
doaj   +1 more source

MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP

Nature Communications
Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in many different cell types.
Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J. Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost, Macarena Hinrichs, Viviana Granato, Mikolaj Nawrocki, Tobis Hub, Volodymyr Tsvilovskyy, Rebekka Medert, Lena-Marie Woelk, Fritz Förster, Huan Li, René Werner, Marcus Altfeld, Samuel Huber, Oliver Biggs Clarke, Marc Freichel, Björn-Philipp Diercks, Chris Meier, Andreas H. Guse   +26 more
doaj   +1 more source

Corrigendum: Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Kris Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

Impaired intestinal calcium absorption and osteopathy in ICR/Mlac-hydro mice with hypoparathyroidism and severe hydronephrosis

Scientific Reports
Abnormal fluid accumulation in the renal pelvis and calyces, with enlargement of the pelvicalyceal system, leads to a devastating disease known as hydronephrosis, which subsequently induces progressive renal impairment and mineral imbalance.
Panan Suntornsaratoon, Kannikar Wongdee, Nithipak Thammayon, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Wacharaporn Tiyasatkulkovit, Sarawut Lapmanee, Krittikan Chanpaisaeng, Surachai Chantip, Narattaphol Charoenphandhu   +9 more
doaj   +1 more source

Impact of Temperature and Substrate Type on the Optical and Structural Properties of AlN Epilayers: A Cross-Sectional Analysis Using Advanced Characterization Techniques

Molecules
AlN, with its ultra-wide bandgap, is highly attractive for modern applications in deep ultraviolet light-emitting diodes and electronic devices. In this study, the surface and cross-sectional properties of AlN films grown on flat and nano-patterned ...
Wenwang Wei, Yi Peng, Yuefang Hu, Xiuning Xu, Quanwen Xie   +4 more
doaj   +1 more source

Synthesis, dyeing performance and surface finishing effects of aminoethyl methacrylate functionalized stilbene fluorescent whitening agents

Scientific Reports
Six novel stilbene fluorescent whitening agents bearing aminoethyl methacrylate groups were synthesized. Their molecular orbital energy levels, thermal stability, dyeing performance, and surface-finishing efficacy on cotton fibers were systematically ...
Meng Ou, Li Hua, Mao-sheng Wan, Bo Wang, Fei-qing Rao   +4 more
doaj   +1 more source

Müller Glia-Vasculature Interactions in the Developing Retina. [PDF]

Glia
Monshietehadi S, Garcia AJ, Smith BE, Tarchick M, Abhayaratne K, Conley A, Feller MB.   +6 more
europepmc   +1 more source