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Frontiers in Cell and Developmental Biology, 2020 In stroke and other neurological diseases, Transient Receptor Potential Melastatin 4 (TRPM4) has been reported to cause oncotic cell death which is due to an excessive influx of sodium ions.
Shunhui Wei +8 more
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Scientific Reports, 2021 Increasing evidence has indicated that adult neurogenesis contributes to brain plasticity, although function of new neurons is still under debate. In opossums, we performed an olfactory-guided behavior task and examined the association between olfactory ...
Beata Tepper +5 more
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Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
Cells, 2021 Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
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Calcium-induced calcium release [PDF]
Current Biology, 2003 Why is calcium so important? Intracellular calcium controls a diverse array of cellular processes from fertilisation through gene transcription, muscle contraction to cell death. Changes in calcium levels can occur in microseconds or hours, they can be microscopic or propagate throughout cells and tissues.How are calcium levels increased within cells ...
Roderick, H. Llewelyn +2 more
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Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
Scientific Reports, 2022 Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the ...
Shunhui Wei +6 more
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Journal of Clinical Endocrinology and Metabolism, 2010 This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population needs for these nutrients in North America conducted a ...
A. Ross +14 more
semanticscholar +1 more source
Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2005 Calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. The objective of this study was to compare the oral bioavailability of calcium from calcium formate, a new experimental dietary calcium supplement, to that of calcium citrate and calcium carbonate.
Hanzlik, Robert P. +2 more
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The Effect of Treatment of Acidosis on Calcium Balance in Patients with Chronic Azotemic Renal Disease [PDF]
, 1967 Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present.
Lemann, Jacob, Jr. +2 more
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HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
Stem Cell Research & Therapy, 2023 Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang +4 more
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Genes and Diseases, 2022 Proximal tubule (PT) transports most of the renal Ca2+, which was usually described as paracellular (passive). We found a regulated Ca2+ entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates ...
Samuel Shin +5 more
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