Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
Scientific Reports, 2022 Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the ...
Shunhui Wei +6 more
doaj +1 more source
HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
Stem Cell Research & Therapy, 2023 Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang +4 more
doaj +1 more source
Frontiers in Immunology, 2018 S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment
Véronique Schenten +7 more
doaj +1 more source
Preparation and characterization of new hybrid organic/inorganic systems derived from calcium (aminoalkyl)-phosphonates and -phosphonocarboxylates [PDF]
, 2005 We have studied the phenomenon of calcium complexation by lab synthesized amphiphilic (α-aminoalkyl)-phosphonocarboxylic or -phosphonic acids. The electrical conductivity of aqueous solutions of sodium salts of all these acids was measured versus the ...
Al-Ali, Fatima +3 more
core +2 more sources
Cell, 1995 Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles.
openaire +3 more sources
Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side Effect on Colon Carcinogenesis [PDF]
, 2010 Red meat intake is associated with increased risk of colorectal cancer. We have previously shown that haemin, haemoglobin and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci, in the colon of rats.
Belbraouet +14 more
core +3 more sources
Melamine promotes calcium crystal formation in three-dimensional microfluidic device
Scientific Reports, 2019 Melamine, which induces proximal tubular (PT) cell damage has a greater nephrotoxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect can stimulate calcium phosphate (CaP)/calcium oxalate (CaOx) stone formation.
Farai Gombedza +6 more
doaj +1 more source
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators
Nature Methods, 2009 Genetically encoded calcium indicators (GECIs) can be used to image activity in defined neuronal populations. However, current GECIs produce inferior signals compared to synthetic indicators and recording electrodes, precluding detection of low firing ...
L. Tian +13 more
semanticscholar +1 more source
Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map
Frontiers in Endocrinology, 2022 Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow.
Shuang Zhang +5 more
doaj +1 more source
Active regulation of the epidermal calcium profile [PDF]
, 2012 A distinct calcium profile is strongly implicated in regulating the multi-layered structure of the epidermis. However, the mechanisms that govern the regulation of this calcium profile are currently unclear.
Adams, Matthew +2 more
core +2 more sources