Results 31 to 40 of about 2,445,184 (215)
Vascular Calcification and Stone Disease: A New Look towards the Mechanism
Journal of Cardiovascular Development and Disease, 2015 Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors,
Allen J. Yiu +3 more
doaj +1 more source
Bone Reports, 2021 Introduction: Pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP) (Inactivating PTH/PTHrP Signaling Disorders type 2, IPPSD2) are two rare autosomal disorders caused by loss-of-function mutations on either maternal or ...
Andreea Apetrei +8 more
doaj +1 more source
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2019 Objective: To evaluate and compare the remineralization potential of a dentifrice containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in remineralizing artificial carious lesion on enamel.
Ratheesh Rajendran +5 more
semanticscholar +1 more source
Protein kinase A modulation of CaV1.4 calcium channels
Nature Communications, 2016 Phosphorylation of L-type calcium CaV channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates CaV1.4 activity, suggesting a general regulatory mechanism for all L-type calcium channels.
Lingjie Sang, Ivy E. Dick, David T. Yue
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Ca2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains of reduced spatial and temporal extents develop ...
Diana Gil +3 more
doaj +1 more source
Journal of Orthopedic and Spine Trauma, 2016 Introduction: Bone cement leakage is the most common, however, it can have potentially disastrous complications during vertebroplasty and balloon kyphoplasty (BK).
Papaioannou Ioannis +2 more
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Biochemistry and Biophysics Reports, 2021 Parathyroid hormone (PTH) has previously been shown to enhance the transepithelial secretion of Cl− and HCO3− across the intestinal epithelia including Caco-2 monolayer, but the underlying cellular mechanisms are not completely understood.
Rattana Chaimana +7 more
doaj +1 more source
Detecting stoichiometry of macromolecular complexes in live cells using FRET
Nature Communications, 2016 Measuring thein vivo stoichiometry of protein-protein interactions is challenging. Here the authors take a FRET-based approach, quantifying stoichiometry based on ratiometric comparison of donor and acceptor fluorescence, and apply their method to report
Manu Ben-Johny +2 more
doaj +1 more source
Calcium and Excitation-Contraction Coupling in the Heart
Circulation Research, 2017 Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+]i). Normal function requires that [Ca2+]i be sufficiently high in systole and low in diastole.
D. Eisner +3 more
semanticscholar +1 more source
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel
Scientific ReportsTransient receptor potential melastatin 4 (TRPM4) channel, a monovalent cation channel, plays a crucial role in various neurological disorders. We previously showed that TRPM4 activity can be blocked by our antibodies: M4P, which targets rat TRPM4 and ...
Shunhui Wei +6 more
doaj +1 more source