Results 41 to 50 of about 2,988,254 (363)
Frontiers in Neuroanatomy, 2020 In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper +6 more
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Bone Reports, 2021 Introduction: Pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP) (Inactivating PTH/PTHrP Signaling Disorders type 2, IPPSD2) are two rare autosomal disorders caused by loss-of-function mutations on either maternal or ...
Andreea Apetrei +8 more
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, 2002 This lithograph answers the question: Where do the elements around us come from? Many are produced in stars, and liberated when these stars explode. It features an attractive image of the remains of an exploded star, taken by NASA's new Chandra X-ray ...
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Vascular Calcification and Stone Disease: A New Look towards the Mechanism
Journal of Cardiovascular Development and Disease, 2015 Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors,
Allen J. Yiu +3 more
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Calcium-rich Gap Transients: Solving the Calcium Conundrum in the Intracluster Medium [PDF]
, 2014 X-ray measurements suggest the abundance of Calcium in the intracluster medium is higher than can be explained using favored models for core-collapse and Type Ia supernovae alone.
Kasliwal, Mansi M. +2 more
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation
Nature Communications, 2016 Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of ...
Ivy E. Dick +3 more
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Frontiers in Molecular Biosciences, 2022 Ca2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains of reduced spatial and temporal extents develop ...
Diana Gil +3 more
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The volumetric rate of calcium-rich transients in the local universe [PDF]
, 2018 We present a measurement of the volumetric rate of `calcium-rich' optical transients in the local universe, using a sample of three events from the Palomar Transient Factory (PTF).
Frohmaier, C. +3 more
core +3 more sources