Results 31 to 40 of about 149,086 (250)

Vitamin E and quercetin attenuated the reproductive toxicity mediated by lead acetate in male Wistar

Bulletin of the National Research Centre, 2022
Background Heavy metals are well documented to induce reproductive toxicity. This study was designed to investigate the role of vitamin E and quercetin on reproductive toxicity mediated by lead acetate in male Wistar rats.
Wahab Adekunle Oyeyemi, Adeniran Oluwadamilare Akinola, Oore-oluwapo Ololade Daramola, Ikponmwosa Aikpitanyi, Opeyemi Tosin Durotoluwa, Precious-Gift Olohigbe Alele, Iyesogie Osaretin Ogieriakhi, Tseye Daisy Okoro   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Enhancing urease enzyme production of Bacillus subtilis OQ119616 by different calcium salts using Box–Behnken statistical experimental design [PDF]

Assiut University Journal of Multidisciplinary Scientific Research
Urease production by bacteria represents the key elements of several environmental processes including wastewater treatment, fertilizers management, and bio-cement processes. Maximizing urease production from the microbial strains is considered the first
Raghad hasan, Amal Daniala, Ghada Abd-Elmonsef Mahmoud, Refaat Mohamed   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cockle-shell biowaste as a low-cost renewable source for synthesis of calcium acetate monohydrate as a precursor of quasi-amorphous calcium pyrophosphate hydrate

Current Research in Green and Sustainable Chemistry
Calcium-rich seashell wastes can be used as renewable materials to prepare value-added compounds. This work proposed an eco-environmental preparation of calcium pyrophosphate by using cockle-shell biowaste as a low-cost renewable calcium source for the ...
Somphob Thompho, Nongnuch Laohavisuti, Chaowared Seangarun, Banjong Boonchom, Pesak Rungrojchaipon, Wimonmat Boonmee, Somkiat Seesanong, Sirichet Punthipayanon   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Dietary vinegar prevents kidney stone recurrence via epigenetic regulationsResearch in context

EBioMedicine, 2019
Background: Epidemiological evidence of over 9000 people suggests that daily intake of vinegar whose principal bioactive component is acetic acid is associated with a reduced risk of nephrolithiasis.
Wei Zhu, Yang Liu, Yu Lan, Xiaohang Li, Lianmin Luo, Xiaolu Duan, Ming Lei, Guanzhao Liu, Zhou Yang, Xin Mai, Yan Sun, Li Wang, Suilin Lu, Lili Ou, Wenqi Wu, Zanlin Mai, Dongliang Zhong, Chao Cai, Zhijian Zhao, Wen Zhong, Yongda Liu, Yin Sun, Guohua Zeng   +22 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source