Results 111 to 120 of about 2,159,124 (309)

The fourth-generation Calcium channel blocker: Cilnidipine

Indian Heart Journal, 2013
Several classes of antihypertensive agents have been in clinical use, including diuretics, α-blockers, β-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor blockers (ARB), and organic calcium channel blockers (CCBs).
K. Sarat Chandra, G. Ramesh
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Has the controversy over the use of calcium channel blockers in coronary artery disease been resolved?

, 2005
Calcium channel blockers are used in the treatment of hypertension and angina. The negative findings on cardiovascular outcomes with some short-acting formulations of calcium channel blockers, described in the 1990s, have led to a much reduced use of ...
Doggrell, Sheila A., Doggrell, Sheila
core   +1 more source

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Najl V Valeyev, Nikolay V Kotov, Kotov, Nikolay, Bates D., Declan G. Heslop-Harrison (7606778), Heslop-Harrison, Pat, Postlethwaite, Ian, Declan G Bates, Najl V. Valeyev (7606775), Valeyev N., Ian Postlethwaite, Kotov N., Ian Postlethwaite (36312), Valeyev, Najil, Pat Heslop-Harrison, Nikolay V. Kotov (7606781), Bates, Declan, Heslop-Harrison P., Postlethwaite I., Declan G. Bates (2615086)   +19 more
core   +1 more source

SUMOylation regulates USP5-Cav3.2 calcium channel interactions

Molecular Brain, 2019
Cav3.2 calcium channels play a key role in nociceptive signaling in the primary afferent pain pathway. We have previously reported the regulation of Cav3.2 calcium channels by the deubiquitinase USP5 and its importance for regulating peripheral ...
Agustin Garcia-Caballero, Fang-Xiong Zhang, Lina Chen, Said M’Dahoma, Junting Huang, Gerald W. Zamponi   +5 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current.

, 2017
AIM The L-type voltage-gated calcium channel Cav1.2 mediates the calcium influx into cells upon membrane depolarization. The list of cardiopathies associated to Cav1.2 dysfunctions highlights the importance of this channel in cardiac physiology. Calcium/
Rougier, Jean-Sébastien, Nafzger, Sabine Naomi   +1 more
core   +1 more source

A Modern View on the Treatment for Acute Calcium Channel Blocker Poisoning

Неотложная медицинская помощь
BACKGROUND. At the beginning of the 21st century, the structure of acute exotoxicoses changed, in particular, an increase in poisoning by drugs that mainly affect the cardiovascular system, including calcium channel blockers, was noted.
A. Yu. Simonova, K. K. Ilyashenko, M. M. Potskhveriya, M. V. Belova, L. R. Asanova   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The involvement of calcium carriers and of the vacuole in the glucose-induced calcium signaling and activation of the plasma membrane H+-ATPase in Saccharomyces cerevisiae cells.

, 2012
Previous work from our laboratories demonstrated that the sugar-induced activation of plasma membrane H+-ATPase in Saccharomyces cerevisiae is dependent on calcium metabolism with the contribution of calcium influx from external medium.
Tisi, Renata, E.M.C. Ribeiro, Bouillet, L. E. M., E. Perovano, R. Tisi, Martegani, Enzo, Trópia, Maria José Magalhães, Cardoso, A. S., M.J.M. Trópia, R.R. Pereira, Tisi, R., Fietto, Luciano Gomes, Brandão, Rogélio Lopes, Ribeiro, E. M. C., Pereira, R. R., Trópia, M. J. M., Brandão, R. L., R.L. Brandão, L.G. Fietto, L.E.M. Bouillet, E. Martegani, I.M. Castro, Perovano, Eduardo, Fietto, L. G., Castro, I. M., Cardoso, Anamaria de Souza, Bouillet, Leoneide Érica Maduro, Perovano, E., A.S. Cardoso, Castro, Ieso de Miranda, Martegani, E., Ribeiro, Erica Milena de Castro   +31 more
core   +1 more source