Results 261 to 270 of about 625,880 (309)

Calcium channels in hepatocytes

Journal of Hepatology, 1988
In living cells, the concentration of cytosolic Ca :+ ([Ca2+]i) is maintained at a level ranging from 50 to 200 nM. The cytosolic Ca 2+ is actively extruded from the cell by a Ca2+-pump present in the plasma membrane and/or by Ca2+/Na + exchange. In resting cells, Ca 2+ is accumulated essentially in the endoplasmic ' reticulum and, to a lesser extent ...
J P, Mauger, M, Claret
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Calcium, calcium channels, and calcium channel antagonists

Canadian Journal of Physiology and Pharmacology, 1990
Voltage-dependent Ca2+ channels are an important pathway for Ca2+ influx in excitable cells. They also represent an important site of action for a therapeutic group of agents, the Ca2+ channel antagonists. These drugs enjoy considerable use in the cardiovascular area including angina, some arrhythmias, hypertension, and peripheral vascular disorders ...
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Calcium channels and calcium channel antagonists

Annals of Neurology, 1987
AbstractChanges in free intracellular Ca2+ levels provide signals that allow nerve and muscle cells to respond to a host of external stimuli. A major mechanism for elevating the level of intracellular Ca2+ is the influx of extracellular Ca2+ through voltage‐dependent channels in the cell membrane.
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Calcium channels

Current Opinion in Nephrology and Hypertension, 1994
A key step in renal calcium reabsorption is dihydropyridine-sensitive calcium entry across the apical membrane of the distal tubule. Electrophysiologic studies have confirmed the existence of calcium channels that may mediate this pathway. Molecular studies of voltage-dependent calcium channels have revealed a surprising degree of heterogeneity.
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Calcium Channel Ligands

Annual Review of Pharmacology and Toxicology, 1987
The Ca2+ channel blockers, diltiazem, nifedipine, and vcrapamil, are now well-established members of the therapeutic armamentarium employed in cardiovascular disease including, but not limited to, angina in its several forms, hypertension, some cardiac arrhythmias including supraventricular tachycardia, congestive heart failure, and hypertrophic ...
D J, Triggle, R A, Janis
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Calcium channel blockers and calcium channels

2004
In 1883, Ringer showed that to get isolated hearts to contract, it was necessary to have Ca2+ ions in the perfusion medium [421]. This was the first demonstration of the critical role of calcium in cellular activity. Remarkably, a hundred years passed before the importance of calcium was recognized in processes other than muscle contraction, and almost
Eric Ertel, Théophile Godfraind
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Calcium channel modulators and calcium channels.

Biochemical Society symposium, 1986
In recent years calcium has become recognized as an important 'second messenger', in that an increase in free intracellular calcium ion concentration is involved in many aspects of cellular activation. In excitable cells such as smooth muscle or cardiac tissue an influx of extracellular calcium ions through voltage sensitive calcium channels plays a ...
R, Towart, M, Schramm
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Calcium Channel Blockers

AACN Advanced Critical Care, 1992
Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Inactivation of calcium channels

Comparative Biochemistry and Physiology Part A: Physiology, 1989
Rapid progress in our understanding of the properties and functions of voltage-gated calcium channels had produced the need for an update to our previous review of calcium inactivation. The major elements of change included in this review are: 1.
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