Results 21 to 30 of about 464,946 (417)
An in silico drug repurposing pipeline to identify drugs with the potential to inhibit SARS-CoV-2 replication [PDF]
Informatics in Medicine Unlocked (2023): 101387, 2021 Drug repurposing provides an opportunity to redeploy drugs, which ideally are already approved for use in humans, for the treatment of other diseases. For example, the repurposing of dexamethasone and baricitinib has played a crucial role in saving patient lives during the ongoing SARS-CoV-2 pandemic.
arxiv +1 more source
Calcium-channel blockers and anaesthesia [PDF]
Canadian Journal of Anaesthesia, 1991 Verapamil was the first calcium-channel blocker (CCB). It has been used since 1962 in Europe then in Japan for its antiarrhythmic and coronary vasodilator effects. The CCB have become prominent cardiovascular drugs during the last 15 years. Many experimental and clinical studies have defined their mechanism of action, the effects of new drugs in this ...
Pierre Foëx +2 more
openaire +3 more sources
Pharmaceuticals, 2023 Renin-angiotensin system (RAS) inhibitors and calcium channel blockers (CCB) are often used together in chronic kidney disease (CKD). The PubMed, EMBASE, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) in ...
Mingming Zhao +9 more
doaj +1 more source
Grand Challenge for Ion Channels: an Underexploited Resource for Therapeutics [PDF]
, 2010 In the last decade, only a few new ion channel drugs have reached the market according to the Food and Drug Administration. These include nateglinide, a non-sulfonylurea blocker of KATP channel used in type II diabetes; ziconotide, a N-type calcium ...
Camerino, Diana Conte +1 more
core +4 more sources
Medicine, 2003 Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features.
Ian M Whyte +5 more
openaire +3 more sources
Calcium Channel Blocker Overdose Simulation
MedEdPORTAL, 2015 Introduction Accidental poisoning and drug overdose are a common occurrence in the emergency medicine setting. Often it is unknown what substances the patient has taken.
Michael Maniaci +2 more
doaj +1 more source
Drug-related Atrioventricular Block: Is It a Benign Condition? [PDF]
, 2016 Introduction: Prognosis of the patients with beta blocker or calcium channel blocker induced AV block is not well known to date.Methods: All patients with symptomatic second-degree or third-degree atrioventricular block (AV) referred to our institution ...
Akbarzadeh, Mohammad Ali +5 more
core +3 more sources
Pre-injury beta blocker use does not affect the hyperdynamic response in older trauma patients
Journal of Emergencies, Trauma and Shock, 2014 Purpose: Trauma dogma dictates that the physiologic response to injury is blunted by beta-blockers and other cardiac medications. We sought to determine how the pre-injury cardiac medication profile influences admission physiology and post-injury ...
David C Evans +8 more
doaj +1 more source
Inhibition of Escherichia coli chemotaxis by omega-conotoxin, a calcium ion channel blocker [PDF]
, 1993 Escherichia coli chemotaxis was inhibited by omega-conotoxin, a calcium ion channel blocker. With Tris-EDTA-permeabilized cells, nanomolar levels of omega-conotoxin inhibited chemotaxis without loss of motility.
Adler, Julius +2 more
core +3 more sources
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults
Critical Care Medicine, 2017 Objective: To provide a management approach for adults with calcium channel blocker poisoning. Data Sources, Study Selection, and Data Extraction: Following the Appraisal of Guidelines for Research & Evaluation II instrument, initial voting statements ...
M. St-Onge +16 more
semanticscholar +1 more source