Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]
, 2003 <b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A. +4 more
core +1 more source
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Journal of Infectious Diseases, 2018 No therapeutics are approved for the treatment of filovirus infections. Bepridil, a calcium channel blocker developed for treating angina, was identified as a potent inhibitor of filoviruses in vitro, including Ebola and Marburg viruses, and Ebola virus ...
Lisa Evans DeWald +15 more
semanticscholar +1 more source
Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin) : study protocol for a randomized controlled trial [PDF]
, 2014 Peer reviewedPublisher ...
Anson, Ken +12 more
core +2 more sources
Diltiazem for clozapine-induced generalized hyperhidrosis [PDF]
Mental Health Clinician, 2023 Background Clozapine can be associated with significant side effects and tolerability issues. Hyperhidrosis occurs less commonly and is unanticipated by clinicians because of clozapine's significant anticholinergic activity.
Kenton Emma M. PharmD +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2018 Immunosuppression may occur for a number of reasons related to an individual’s frailty, debility, disease or from therapeutic iatrogenic intervention or misadventure. A large percentage of morbidity and mortality in immunodeficient populations is related
J. D'Elia, L. Weinrauch
semanticscholar +1 more source
Strategies for studying permeation at voltage-gated ion channels [PDF]
, 1991 Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core +1 more source
Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]
, 2003 <b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT<sub>4</sub> receptors.
Andrew C Rankin +32 more
core +2 more sources
Blockade of current through single calcium channels by trivalent lanthanide cations. Effect of ionic radius on the rates of ion entry and exit. [PDF]
, 1990 Currents flowing through single dihydropyridine-sensitive Ca2+ channels were recorded from cell-attached patches on C2 myotubes. In the presence of dihydropyridine agonist to prolong the duration of single-channel openings, adding micromolar ...
Lansman, JB
core +2 more sources
Antiarrhythmic drug usage and prostate cancer: a population-based cohort study
Asian Journal of Andrology, 2018 Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent.
Li-Ting Kao +3 more
doaj +1 more source