Results 31 to 40 of about 390,662 (343)

A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain

open access: yesPain, 2015
T-type Cav3.2 calcium channels represent a novel target for neuropathic pain modulation. Preclinical studies with ABT-639, a peripherally acting highly selective T-type Cav3.2 calcium channel blocker, showed dose-dependent reduction of pain in multiple ...
D. Ziegler   +4 more
semanticscholar   +1 more source

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

open access: yes, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu   +10 more
core   +1 more source

Pharmacological, Pharmacokinetic, and Clinical Properties of Benidipine Hydrochloride, a Novel, Long-Acting Calcium Channel Blocker

open access: yesJournal of Pharmacological Sciences, 2006
.: Benidipine is a dihydropyridine-derived calcium channel blocker developed in Japan, with several unique mechanisms of action, that is, triple calcium channels (L, N, and T) blocking action with a membrane approach.
Kozo Yao, Ken Nagashima, Hiroyuki Miki
doaj   +1 more source

Calcium Channel Blockers and Hypertension

open access: yesJournal of Cardiovascular Pharmacology and Therapeutics, 2014
Effective treatment of high blood pressure (BP) represents a key strategy for reducing the burden of hypertension-related cardiovascular and renal diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide.
TOCCI, GIULIANO   +6 more
openaire   +3 more sources

Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum

open access: yesParasite, 2005
Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine.
Randrianarivelojosia M., Jambou R.
doaj   +1 more source

Statin, Calcium Channel Blocker and Beta Blocker Therapy May Decrease the Incidence of Tuberculosis Infection in Elderly Taiwanese Patients with Type 2 Diabetes

open access: yesInternational Journal of Molecular Sciences, 2015
Background: It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed.
M. Lee   +6 more
semanticscholar   +1 more source

Gingival hyperplasia induced by Nifedipine: case report [PDF]

open access: yes, 2002
Nifedipine, a calcium channel blocker, is commonly used in the treatment of cardiovascular disorders. In this paper a case report is presented which describes a patient medicated with Nifedipine for angina pectoris and arterial hypertension, who ...
Pićurić Ivana, Đurić Milanko
core   +1 more source

Phenytoin- and amlodipine-induced gingival overgrowth

open access: yesJournal of Dental Sciences, 2012
Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers.
Ching-Wen Chang   +2 more
doaj   +1 more source

Treatment for calcium channel blocker poisoning: A systematic review

open access: yesClinical toxicology, 2014
Context. Calcium channel blocker poisoning is a common and sometimes life-threatening ingestion. Objective. To evaluate the reported effects of treatments for calcium channel blocker poisoning.
M. St-Onge   +13 more
semanticscholar   +1 more source

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]

open access: yes, 2008
Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S.   +5 more
core   +2 more sources

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