Results 251 to 260 of about 238,547 (309)
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L-type calcium channels: the low down.
Journal of Neurophysiology, 2004L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihydropyridines.
D. Lipscombe +2 more
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Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
Nature Cell Biology, 2000A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are ...
I. Dzhura +4 more
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Assays for L-type voltage gated calcium channels
Analytical Biochemistry, 2022Voltage gated calcium channels (VGCCs) are pursued as drug targets for neurodegenerative and cardiovascular diseases. High throughput drug screening targeting VGCCs depends on patch-clamp electrophysiology or fluorophore-based calcium imaging that requires powerful equipment and specialized expertise thus leading to cost escalation.
G.M. Archana +2 more
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L-Type Calcium Channel Disease
2008In recent years, the progress of molecular genetics of inherited arrhythmogenic diseases portrays an unexpected complexity of clinical phenotypes associated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of
Ruan Y +3 more
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Current Pharmaceutical Design, 2006
The Ca2+ channel blockers represent a successful group of therapeutic agents directed against cardiovascular targets, including hypertension and angina. These drugs, including the first-generation verapamil, nifedipine and diltiazem are directed against a subclass of voltage-gated Ca2+ channel - the L-type channel.
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The Ca2+ channel blockers represent a successful group of therapeutic agents directed against cardiovascular targets, including hypertension and angina. These drugs, including the first-generation verapamil, nifedipine and diltiazem are directed against a subclass of voltage-gated Ca2+ channel - the L-type channel.
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Osteoblastic cells have L-type calcium channels
Bone and Mineral, 1989Whole cell patch clamp studies on osteoblast-like rat osteosarcoma cells (ROS 17/2.8) show the existence of L-type calcium channels in the cell membrane. Measurements were carried out at both 21 and 37 degrees C. With isotonic CsCl in the pipette and a bathing medium containing either 110 or 10 mM Ba2+, a strong depolarizing pulse was required to ...
C, Grygorczyk, R, Grygorczyk, J, Ferrier
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Circulation, 2008
Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. In this study we test the hypothesis that a mobile carboxyl-terminal cleavage product (CCt) of the cardiac L-type calcium channel (Ca V 1.2) auto-regulates expression.
Elizabeth A Schroder +2 more
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Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. In this study we test the hypothesis that a mobile carboxyl-terminal cleavage product (CCt) of the cardiac L-type calcium channel (Ca V 1.2) auto-regulates expression.
Elizabeth A Schroder +2 more
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L-Type Calcium Channel Recording
2006Calcium channels constitute a large family of voltageand ligand-operated ionchannels. They share several structural similarities with voltage-gated Naand K-channels. All three channel populations appear to originate from the same gene superfamily. Ca channels are ubiquitous, they can be found in almost any type of excitable and most unexcitable cells ...
Uta C. Hoppe +3 more
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Molecular Pharmacology of Non-L-type Calcium Channels
Current Pharmaceutical Design, 2005Voltage-gated calcium channels are key sources of calcium entry into the cytosol. Mutations in calcium channels have been implicated in numerous disorders such as migraine, incomplete congenital X-linked stationary night blindness, epilepsy, and ataxia, and they are important therapeutic targets for the treatment of pain, stroke, hypertension, and ...
Clinton J, Doering, Gerald W, Zamponi
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The Biochemical Properties of L-Type Calcium Channels
Journal of Cardiovascular Pharmacology, 1988Activation of the cardiac beta-adrenergic receptor stimulates cAMP levels and activates cAMP-dependent protein kinase. The kinase phosphorylates the calcium channel and enhances thereby the availability and the number of channels that are opened during depolarization. The increased calcium influx leads then to a positive inotropic response. The calcium
F, Hofmann +3 more
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