Results 261 to 270 of about 20,375,767 (303)

The Biochemical Properties of L-Type Calcium Channels

Journal of Cardiovascular Pharmacology, 1988
Activation of the cardiac beta-adrenergic receptor stimulates cAMP levels and activates cAMP-dependent protein kinase. The kinase phosphorylates the calcium channel and enhances thereby the availability and the number of channels that are opened during depolarization. The increased calcium influx leads then to a positive inotropic response. The calcium
F, Hofmann, H J, Oeken, T, Schneider, M, Sieber   +3 more
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Interaction of the L-Type Calcium Channel with Calcium Channel Blockers

1996
The contribution of the primary structure and the β subunit to the block of the L-type α1C calcium channel was studied. The α1C-a and the α1C-b subunits were truncated at aa 1733 and 1728, respectively, and were expressed stably in human embryonic kidney (HEK) 293 cells (α1C-at and α1C-bt cell line). The β3 subunit was coexpressed stably with the α1C-a
Franz Hofmann, Norbert Klugbauer, Lubica Lacinová, Claudia Seisenberger, Angela Schuster, Andrea Welling   +5 more
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Regulation of the L-type calcium channel

Trends in Pharmacological Sciences, 1987
Abstract The voltage-operated L-type calcium channel is regulated by protein phosphorylation and G proteins in a variety of tissues and eukaryotes including non-excitable cells. The 165 kDa protein of the dihydropyridine receptor from rabbit skeletal muscle contains all the regulatory sites of an L-type calcium channel and the calcium conducting unit
Franz Hofmann, Wolfgang Nastainczyk, Axel Röhrkasten, Toni Schneider, Manfred Sieber   +4 more
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Molecular Pharmacology of Non-L-type Calcium Channels

Current Pharmaceutical Design, 2005
Voltage-gated calcium channels are key sources of calcium entry into the cytosol. Mutations in calcium channels have been implicated in numerous disorders such as migraine, incomplete congenital X-linked stationary night blindness, epilepsy, and ataxia, and they are important therapeutic targets for the treatment of pain, stroke, hypertension, and ...
Clinton J, Doering, Gerald W, Zamponi
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Osteoblastic cells have L-type calcium channels

Bone and Mineral, 1989
Whole cell patch clamp studies on osteoblast-like rat osteosarcoma cells (ROS 17/2.8) show the existence of L-type calcium channels in the cell membrane. Measurements were carried out at both 21 and 37 degrees C. With isotonic CsCl in the pipette and a bathing medium containing either 110 or 10 mM Ba2+, a strong depolarizing pulse was required to ...
C, Grygorczyk, R, Grygorczyk, J, Ferrier
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L-type calcium channels and calcium channel ligands

1992
Abstract L-type calcium channels possess high affinity drug binding domains for different chemical classes of calcium channel active drugs. Reversible binding experiments using radiolabeled and fluorescently labeled calcium antagonists revealed tight allosteric coupling between several distinct drug binding domains and divalent cation binding sites ...
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L-Type Calcium Channel Recording

2006
Calcium channels constitute a large family of voltageand ligand-operated ionchannels. They share several structural similarities with voltage-gated Naand K-channels. All three channel populations appear to originate from the same gene superfamily. Ca channels are ubiquitous, they can be found in almost any type of excitable and most unexcitable cells ...
Uta C. Hoppe, Mathias C. Brandt, Guido Michels, Michael Lindner   +3 more
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An L-type Calcium Channel in Renal Epithelial Cells

Journal of Membrane Biology, 1996
A voltage-activated Ca++ channel has been identified in the apical membranes of cultured rabbit proximal tubule cells using the patch-clamp technique. With 105 mm CaCl2 solution in the pipette and 180 NaAsp in the bath, the channel had a conductance of 10.4 +/- 1.0 pS (n = 8) in on-cell patches, and 9.8 +/- 1.1 pS (n = 8) in inside-out patches. In both
M I, Zhang, R G, O'Neil
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Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel

European Biophysics Journal, 2009
We study numerically the local dynamics of the intracellular calcium concentration in the vicinity of a voltage- and calcium-dependent plasma membrane L-type calcium channel. To account for the low number of Ca(2+) ions and buffer molecules present in sub-femtoliter volumes, we use an exact stochastic simulation algorithm including diffusion.
Frederic, von Wegner, R H A, Fink
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L-type calcium channel blockade attenuates morphine withdrawal: In vivo interaction between L-type calcium channels and corticosterone

Hormones and Behavior, 2008
Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated.
Saeed, Esmaeili-Mahani, Yadollah, Fathi, Fereshteh, Motamedi, Farhad, Hosseinpanah, Abolhassan, Ahmadiani   +4 more
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