Results 251 to 260 of about 20,375,767 (303)

From Marine Peptides to Oncology: The Therapeutic Potential of Conotoxins in Cancer Treatment. [PDF]

Chem Biodivers
Awais S, Javed MA, Ali R, Shahid M, Shahid MA, Masaud H, Ali N.   +6 more
europepmc   +1 more source

Voltage-gated calcium channels as key regulators of neuronal differentiation in the immortalized dorsal root ganglion neuronal cell line F11. [PDF]

Sci Rep
López D, Brea J, Barro M, Loza MI, Martínez AL.   +4 more
europepmc   +1 more source

Advances in Understanding Calcium Sensitization in Gastrointestinal Smooth Muscles: Pathways, Interstitial Cells, and Disease. [PDF]

J Neurogastroenterol Motil
Perrino BA, Lee JY, Koh SD.
europepmc   +1 more source

Correction for Qiu et al., Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

L-Type Calcium Channels Modulation by Estradiol

Molecular Neurobiology, 2016
Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium-and other processes such as gene expression-in excitable cells.
Vega-Vela, Nelson A., Osorio, Daniel, Ávila-Rodriguez, Marco, Gonzalez, Janneth, García-Segura, Luis M., Echeverria, Valentina, Barreto, George E.   +6 more
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Assays for L-type voltage gated calcium channels

Analytical Biochemistry, 2022
Voltage gated calcium channels (VGCCs) are pursued as drug targets for neurodegenerative and cardiovascular diseases. High throughput drug screening targeting VGCCs depends on patch-clamp electrophysiology or fluorophore-based calcium imaging that requires powerful equipment and specialized expertise thus leading to cost escalation.
G.M. Archana, R.C. Arunkumar, R.V. Omkumar   +2 more
openaire   +2 more sources

L-Type Calcium Channel Disease

2008
In recent years, the progress of molecular genetics of inherited arrhythmogenic diseases portrays an unexpected complexity of clinical phenotypes associated with mutations in several genes that control cardiac excitability. Among the most recent findings, the voltage-gated L-type cardiac calcium channel (Cav1.2) has been involved in the pathogenesis of
Ruan Y, Napolitano C, BLOISE, RAFFAELLA, PRIORI, SILVIA GIULIANA   +3 more
openaire   +1 more source

L-Type Calcium Channels: The Low Down

Journal of Neurophysiology, 2004
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihydropyridines.
Diane, Lipscombe, Thomas D, Helton, Weifeng, Xu   +2 more
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L-Type Calcium Channels

Current Pharmaceutical Design, 2006
The Ca2+ channel blockers represent a successful group of therapeutic agents directed against cardiovascular targets, including hypertension and angina. These drugs, including the first-generation verapamil, nifedipine and diltiazem are directed against a subclass of voltage-gated Ca2+ channel - the L-type channel.
openaire   +2 more sources