Results 261 to 270 of about 238,547 (309)

L-type calcium channel blockade attenuates morphine withdrawal: In vivo interaction between L-type calcium channels and corticosterone

Hormones and Behavior, 2008
Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated.
Saeed, Esmaeili-Mahani, Yadollah, Fathi, Fereshteh, Motamedi, Farhad, Hosseinpanah, Abolhassan, Ahmadiani   +4 more
openaire   +2 more sources

Regulation of the L-type calcium channel

Trends in Pharmacological Sciences, 1987
Abstract The voltage-operated L-type calcium channel is regulated by protein phosphorylation and G proteins in a variety of tissues and eukaryotes including non-excitable cells. The 165 kDa protein of the dihydropyridine receptor from rabbit skeletal muscle contains all the regulatory sites of an L-type calcium channel and the calcium conducting unit
Franz Hofmann, Wolfgang Nastainczyk, Axel Röhrkasten, Toni Schneider, Manfred Sieber   +4 more
openaire   +1 more source

L-type calcium channels and calcium channel ligands

1992
Abstract L-type calcium channels possess high affinity drug binding domains for different chemical classes of calcium channel active drugs. Reversible binding experiments using radiolabeled and fluorescently labeled calcium antagonists revealed tight allosteric coupling between several distinct drug binding domains and divalent cation binding sites ...
openaire   +1 more source

Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels

2012
Mast cells play central roles in adaptive and innate immunity. IgE-dependent stimulation of the high-affinity IgE receptor (FcεRI) results in rapid secretion of various proinflammatory chemical mediators and cytokines. All of the outputs depend to certain degrees on an increase in the intracellular Ca(2+) concentration, and influx of Ca(2+) from the ...
Yoshihiro, Suzuki, Toshio, Inoue, Chisei, Ra   +2 more
openaire   +2 more sources

Interaction of the L-Type Calcium Channel with Calcium Channel Blockers

1996
The contribution of the primary structure and the β subunit to the block of the L-type α1C calcium channel was studied. The α1C-a and the α1C-b subunits were truncated at aa 1733 and 1728, respectively, and were expressed stably in human embryonic kidney (HEK) 293 cells (α1C-at and α1C-bt cell line). The β3 subunit was coexpressed stably with the α1C-a
Franz Hofmann, Norbert Klugbauer, Lubica Lacinová, Claudia Seisenberger, Angela Schuster, Andrea Welling   +5 more
openaire   +1 more source

Calmodulin supports both inactivation and facilitation of L-type calcium channels

Nature, 1999
R. D. Zühlke, G. Pitt, K. Deisseroth, R. Tsien, H. Reuter   +4 more
semanticscholar   +1 more source

L-type calcium channel structure and function

1996
The frequency and force of contraction of the heart is primarily controlled by an influx of calcium across the cell membrane during the action potential. The best characterized pathway for calcium entry in atrial and ventricular cells are voltage-dependent calcium channels. Cardiac myocytes contain two types of voltage-dependent calcium channels, the T-
Franz Hofmann, Martin Biel
openaire   +1 more source

L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.

Physiological Reviews, 2014
F. Hofmann, V. Flockerzi, S. Kahl, J. Wegener   +3 more
semanticscholar   +1 more source

Plasticity of Neuronal L‐Type Calcium Channels

Annals of the New York Academy of Sciences, 1988
Govoni, S, BATTAINI, FIORENZO MARIA, Magnoni, SM, Lucchi, L, Rius, RA, TRABUCCHI, MARCO MARIO   +5 more
openaire   +3 more sources

L-Type Calcium Channels and Adrenomedullary Secretion

1988
On the basis that the calcium removal from solutions perfusing cat adrenal glands abolished acetylcholine-evoked catecholamine release, and that acetylcholine caused some increase in membrane permeability to common species of ions including Ca, particularly at the muscle end-plate (Del Castillo and Katz, 1956), Douglas and Rubin (1961) coined the ...
C. R. Artalejo, M. G. López, C. F. Castillo, M. A. Moro, A. G. García   +4 more
openaire   +1 more source