Results 21 to 30 of about 238,547 (309)
Hydrogen sulfide regulates the colonic motility by inhibiting both L-type calcium channels and BKCa channels in smooth muscle cells of rat colon. [PDF]
PLoS ONE, 2015 To examine the hypothesis that hydrogen sulfide (H2S) regulates the colonic motility by modulating both L-type voltage-dependent calcium channels and large conductance Ca2+-activated K+ (BKCa) channels.Immunohistochemistry was performed on rat colonic ...
Xiaojing Quan +5 more
doaj +1 more source
Autoregulation of Cardiac l-Type Calcium Channels [PDF]
Trends in Cardiovascular Medicine, 2009 l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart.
Jonathan, Satin, Elizabeth A, Schroder
openaire +2 more sources
Cellular Physiology and Biochemistry, 2015 Background/Aims: Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular ...
Xiaoyu Liu +4 more
doaj +1 more source
Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. [PDF]
PLoS ONE, 2013 INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses.
Michelle R Rebello +2 more
doaj +1 more source
Alternative Splicing of L-type CaV1.2 Calcium Channels: Implications in Cardiovascular Diseases
Genes, 2017 L-type CaV1.2 calcium channels are the major pathway for Ca2+ influx to initiate the contraction of smooth and cardiac muscles. Alteration of CaV1.2 channel function has been implicated in multiple cardiovascular diseases, such as hypertension and ...
Zhenyu Hu, M. C. Liang, T. Soong
semanticscholar +1 more source
T-type calcium channel: a privileged gate for calcium entry and control of adrenal steroidogenesis
Frontiers in Endocrinology, 2016 Intracellular calcium plays a crucial role in modulating a variety of functions such as muscle contraction, hormone secretion, gene expression or cell growth. Calcium signaling has been however shown to be more complex than initially thought.
Michel Florian Rossier +1 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity.Objective This study investigated the potential interaction between verapamil and glycoalkaloids.Material and methods The cardioactivity of verapamil and glycoalkaloids (α ...
Szymon Chowański +9 more
doaj +1 more source
Nature Communications, 2016 Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we identify FDA-approved calcium channel blockers (CCBs) as potent inhibitors
Guillaume Jacquemet +10 more
semanticscholar +1 more source
CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels
Biological Psychiatry, 2015 Background Cav1.3 voltage-gated L-type calcium channels (LTCCs) are part of postsynaptic neuronal signaling networks. They play a key role in brain function, including fear memory and emotional and drug-taking behaviors.
Alexandra Pinggera +7 more
semanticscholar +1 more source
Circulation Research, 2002 Voltage-gated calcium channels are essential for coupling membrane depolarization to the influx of calcium in all excitable cells. The calcium that flows into excitable cells through voltage-gated calcium channels serves a dual function, generating both electrical and chemical signals. The intracellular events controlled by calcium are diverse and many.
openaire +1 more source