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AACN Advanced Critical Care, 1992
Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Calcium channel blockers are widely used in the treatment of ischemic heart disease, hypertension, and supraventricular tachycardia. The prototype agents, verapamil, nifedipine, and diltiazem, represent three classes of calcium channel blockers, each of which has different pharmacologic effects.
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Calcium Channelopathies: Voltage-Gated Calcium Channels
2007Since the initial identification of native calcium currents, significant progress has been made towards our understanding of the molecular and cellular contributions of voltage-gated calcium channels in multiple physiological processes. Moreover, we are beginning to comprehend their pathophysiological roles through both naturally occurring ...
P J, Adams, T P, Snutch
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Calcium channel modulators and calcium channels.
Biochemical Society symposium, 1986In recent years calcium has become recognized as an important 'second messenger', in that an increase in free intracellular calcium ion concentration is involved in many aspects of cellular activation. In excitable cells such as smooth muscle or cardiac tissue an influx of extracellular calcium ions through voltage sensitive calcium channels plays a ...
R, Towart, M, Schramm
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Calcium channel diversity: multiple roles of calcium channel subunits
Current Opinion in Neurobiology, 2009Until recently we held the simple view that voltage-gated calcium channels consisted of an alpha1 subunit, usually associated with auxiliary beta subunits and alpha(2)delta subunits and that skeletal muscle calcium channels were also associated with a gamma subunit.
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Capacitative calcium entry channels
BioEssays, 1999In the phospholipase C signaling system, Ca(2+) is mobilized from intracellular stores by an action of inositol 1,4,5-trisphosphate. The depletion of intracellular calcium stores activates a calcium entry mechanism at the plasma membrane called capacitative calcium entry.
J W, Putney, R R, McKay
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Targeting voltage-gated calcium channels in neurological and psychiatric diseases
Nature Reviews Drug Discovery, 2015Gerald W. Zamponi
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