Results 61 to 70 of about 595,184 (334)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1) [PDF]

, 2015
Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and ...
Allen M. Spiegel, Breitwieser, Dong, Drude, Enikö Kallay, Fadil M. Hannan, Gerard V. Walls, Gowen, Hannan, Hannan, Harding, Hofer, Hough, Hu, Hu, Huang, Jianxin Hu, John, Kinoshita, Kumar, Leach, Leach, Letz, Letz, Lia-Baldini, Loupy, M. Andrew Nesbit, Miedlich, Nemeth, Nemeth, Nesbit, Pearce, Pearce, Petrel, Rajesh V. Thakker, Raue, Roger D. Cox, Stechman, Tertius A. Hough, Thim, Valerie N. Babinsky, Vargas-Poussou, Watanabe, William D. Fraser, Yamamoto   +44 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E., Cowen, Leah E., Henkel, Thomas, Iyer, Kali R., Porco, Jr., John A., Robbins, Nicole, Whitesell, Luke   +6 more
core   +1 more source

Comparative evaluation of eggshell-derived nano-hydroxyapatite and amniotic membrane as pulpotomy agents in primary teeth: A randomized clinical trial

Journal of Indian Society of Pedodontics and Preventive Dentistry
Background: Despite the clinical success of existing pulpotomy medicaments, the search for novel and economically viable alternatives continues. This study aimed to evaluate and compare the efficacy of eggshell-derived nano-hydroxyapatite (EnHA) and ...
SK Rabiya Shaheen, A. J. Sai Sankar, Vivekanand Kattimani, E. Sridevi, K. Pranitha, K. Siva Sankar   +5 more
doaj   +1 more source

Characterization of Calcium Compounds in Opuntia ficus indica as a Source of Calcium for Human Diet

Journal of Chemistry, 2015
Analyses of calcium compounds in cladodes, soluble dietary fiber (SDF), and insoluble dietary fiber (IDF) of Opuntia ficus indica are reported. The characterization of calcium compounds was performed by using Scanning Electron Microscopy, Energy ...
Isela Rojas-Molina, Elsa Gutiérrez-Cortez, Moustapha Bah, Alejandra Rojas-Molina, César Ibarra-Alvarado, Eric Rivera-Muñoz, Alicia del Real, Ma. de los Angeles Aguilera-Barreiro   +7 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Value of Calcium Hypophosphite and Other Calcium Compounds as Calcium Supplements in Calcium-Low Diets

Experimental Biology and Medicine, 1949
SummaryCalcium hypophosphite is well suited to serve as a supplement for dietary calcium. To what extent the hypophosphite phosphorus is utilized by the organism remains uncertain. The ratio Ca/P in the diet may be varied within a wide range without affecting the calcification of the bones, provided the absolute quantities of each constituent are ...
Jack Greenberg, Arthur E. Meyer
openaire   +3 more sources

Effect of ionic radii on the Curie temperature in Ba1-x-ySrxCayTiO3 compounds [PDF]

, 2016
A series of Ba1-x-ySrxCayTiO3 compounds were prepared with varying average ionic radii and cation disorder on A-site. All samples showed typical ferroelectric behavior.
Alford, N, Berenov, AV, Le Goupil, F
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source