Results 111 to 120 of about 2,798,160 (306)

Multi-scale network imaging in a mouse model of amyloidosis

, 2021
The adult neocortex is not hard-wired but instead retains the capacity to reorganise across multiple spatial scales long into adulthood. Plastic reorganisation occurs at the level of mesoscopic sensory maps, functional neuronal assemblies and synaptic ...
Pavlidi, Pavlina, Zabouri, Nawal, Melgosa-Ecenarro, Leire, Saito, Takashi, Doostdar, Nazanin, Barnes, Samuel J, Saido, Takaomi, Radulescu, Carola I, Kopanitsa, Maksym, Airey, Joseph, Joseph Airey, Carola I. Radulescu, Takaomi Saido, Maksym Kopanitsa, Leire Melgosa-Ecenarro, Samuel J. Barnes, Nazanin Doostdar, Nawal Zabouri, Pavlina Pavlidi, Takashi Saito   +19 more
core   +1 more source

Calcium accumulation or iron deposition: Delving into the temporal sequence of amyotrophic lateral sclerosis pathophysiology in the primary motor cortex

Ibrain
Amyotrophic lateral sclerosis (ALS) causes progressive motor neuron degeneration, but an in vivo understanding of its early pathology remains limited.
Sadegh Ghaderi, Sana Mohammadi, Farzad Fatehi   +2 more
doaj   +1 more source

Live-cell calcium imaging of adherent and non-adherent GL261 cells reveals phenotype-dependent differences in drug responses

BMC Cancer, 2017
Background The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres.
Averey D. Strong, Richard L. Daniels
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo [PDF]

, 2011
Multiphoton imaging (MPI) is widely used for recording activity simultaneously from many neurons in superficial cortical layers in vivo. We combined regenerative amplification multiphoton microscopy (RAMM) with genetically encoded calcium indicators to ...
Mittmann, W., Czubayko, U., Looger, Loren, Kerr, J. ; https://orcid.org/, Looger, L., Wallace, D., Herb, J., Jan T Herb, Schaefer, Andreas T., Denk, W., Wallace, Damian, Winfried Denk, Denk, Winfried, Kerr, J., Jason N D Kerr, Mittmann, Wolfgang, Schaefer, A., Damian J Wallace, Uwe Czubayko, Denk , W., Wolfgang Mittmann, Wallace, D. ; https://orcid.org/, Andreas T Schaefer, Herb, Jan Thomas, Kerr, Jason N D, Czubayko, Uwe, Loren L Looger   +26 more
core   +1 more source

SRDTrans model for simulated calcium imaging data at 0.3 Hz

, 2023
<p>SRDTrans model for simulated calcium imaging data at 0.3 Hz</p ...
Xingye Chen, Xiaowan Hu, Xinyang Li
core   +1 more source

Monitoring correlates of SARS-CoV-2 infection in cell culture using a two-photon-active calcium-sensitive dye

Cellular & Molecular Biology Letters
Background The organism-wide effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection are well studied, but little is known about the dynamics of how the infection spreads in time among or within cells due to the scarcity ...
Domokos Máthé, Gergely Szalay, Levente Cseri, Zoltán Kis, Bernadett Pályi, Gábor Földes, Noémi Kovács, Anna Fülöp, Áron Szepesi, Polett Hajdrik, Attila Csomos, Ákos Zsembery, Kristóf Kádár, Gergely Katona, Zoltán Mucsi, Balázs József Rózsa, Ervin Kovács   +16 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

OnACID: Online analysis of calcium imaging data in real time

, 2017
Optical imaging methods using calcium indicators are critical for monitoring the activity of large neuronal populations in vivo. Imaging experiments typically generate a large amount of data that needs to be processed to extract the activity of the ...
Chklovskii, D., Pnevmatikakis, E. A., Paninski, L., Giovannucci, A., Friedrich, J., Kaufman, M., Churchland, A. K.   +6 more
core