Results 131 to 140 of about 7,712,280 (384)

Calcium imaging in retinal research: challenges and prospects for its application

AIMS Biophysics
Calcium ions are universal signaling particles used alongside other signaling systems in animal cells. Changes in intracellular calcium concentration trigger vital reactions in different types of eukaryotic cells by acting through molecular calcium ...
Yakov S. Veselov, Luba A. Astakhova
doaj   +1 more source

Calcium Imaging of AM Dyes Following Prolonged Incubation in Acute Neuronal Tissue.

PLoS ONE, 2016
Calcium-imaging is a sensitive method for monitoring calcium dynamics during neuronal activity. As intracellular calcium concentration is correlated to physiological and pathophysiological activity of neurons, calcium imaging with fluorescent indicators ...
Morven Cameron, Orsolya Kékesi, John W Morley, Jonathan Tapson, Paul P Breen, André van Schaik, Yossi Buskila   +6 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Calcium accumulation or iron deposition: Delving into the temporal sequence of amyotrophic lateral sclerosis pathophysiology in the primary motor cortex

Ibrain
Amyotrophic lateral sclerosis (ALS) causes progressive motor neuron degeneration, but an in vivo understanding of its early pathology remains limited.
Sadegh Ghaderi, Sana Mohammadi, Farzad Fatehi   +2 more
doaj   +1 more source

Live-cell calcium imaging of adherent and non-adherent GL261 cells reveals phenotype-dependent differences in drug responses

BMC Cancer, 2017
Background The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres.
Averey D. Strong, Richard L. Daniels
doaj   +1 more source

Large-scale two-photon calcium imaging in freely moving mice

Cell, 2021
Weijian Zong, Horst A. Obenhaus, E. R. Skytøen, H. Eneqvist, Nienke L. de Jong, M. Jorge, M. Moser, E. Moser   +7 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Monitoring correlates of SARS-CoV-2 infection in cell culture using a two-photon-active calcium-sensitive dye

Cellular & Molecular Biology Letters
Background The organism-wide effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection are well studied, but little is known about the dynamics of how the infection spreads in time among or within cells due to the scarcity ...
Domokos Máthé, Gergely Szalay, Levente Cseri, Zoltán Kis, Bernadett Pályi, Gábor Földes, Noémi Kovács, Anna Fülöp, Áron Szepesi, Polett Hajdrik, Attila Csomos, Ákos Zsembery, Kristóf Kádár, Gergely Katona, Zoltán Mucsi, Balázs József Rózsa, Ervin Kovács   +16 more
doaj   +1 more source

A Probabilistic Framework for Decoding Behavior From in vivo Calcium Imaging Data

bioRxiv, 2019
Understanding the role of neuronal activity in cognition and behavior is a key question in neuroscience. Previously, in vivo studies have typically inferred behavior from electrophysiological data using probabilistic approaches including bayesian ...
Guillaume Etter, F. Manseau, Sylvain Williams   +2 more
semanticscholar   +1 more source