Results 31 to 40 of about 2,715,719 (363)

A tale of two inositol trisphosphates. [PDF]

, 2016
Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established.

core   +2 more sources

Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review

Frontiers in Endocrinology, 2022
IntroductionIncreased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk.MethodsWe systematically searched four databases. We performed
Randa K. Saad, Randa K. Saad, Malak Ghezzawi, Renee Horanieh, Assem M. Khamis, Katherine H. Saunders, John A. Batsis, Marlene Chakhtoura, Marlene Chakhtoura   +8 more
doaj   +1 more source

Acute hypocalcemia and metabolic alkalosis in children on cation-exchange resin therapy [PDF]

, 2017
Background. Sodium polystyrene sulfonate (SPS) is a chelating agent used for the treatment of hyperkalemia. SPS has a wide range of exchange capacity requiring close monitoring of serum electrolytes.
Barton, Kevin T, Breen, Christine, Kakajiwala, Aadil, Pradhan, Madhura, Rampolla, Elisha   +4 more
core   +3 more sources

Modeling of biological doses and mechanical effects on bone transduction [PDF]

Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011
Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv   +1 more source

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Nature Communications, 2019
Fibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis.
A. Lombardi, Andrew A. Gibb, E. Arif, Devin W. Kolmetzky, D. Tomar, T. Luongo, P. Jadiya, Emma K. Murray, P. Lorkiewicz, G. Hajnóczky, E. Murphy, Z. Arany, D. Kelly, K. Margulies, B. Hill, J. Elrod   +15 more
semanticscholar   +1 more source

Genetic variants of calcium and vitamin D metabolism in kidney stone disease

Nature Communications, 2019
Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a heritability of ~45–60%. We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 ...
S. Howles, A. Wiberg, M. Goldsworthy, Asha L. Bayliss, A. Gluck, M. Ng, E. Grout, C. Tanikawa, Y. Kamatani, C. Terao, A. Takahashi, M. Kubo, K. Matsuda, R. Thakker, B. Turney, D. Furniss   +15 more
semanticscholar   +1 more source

A novel synonymous variant in exon 1 of GNAS gene results in a cryptic splice site and causes pseudohypoparathyroidism type 1A and pseudo-pseudohypoparathyroidism in a French family

Bone Reports, 2021
Introduction: Pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP) (Inactivating PTH/PTHrP Signaling Disorders type 2, IPPSD2) are two rare autosomal disorders caused by loss-of-function mutations on either maternal or ...
Andreea Apetrei, Arnaud Molin, Nicolas Gruchy, Manon Godin, Claire Bracquemart, Antoine Resbeut, Gaëlle Rey, Gwenaël Nadeau, Nicolas Richard   +8 more
doaj  

Nonequilibrium calcium dynamics optimizes the energetic efficiency of mitochondrial metabolism [PDF]

arXiv, 2023
Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of specific cellular processes remains a largely open problem.
arxiv  

Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes [PDF]

J. Biol. Phys. 35(4) (2009) 383-411, 2009
Recent years have witnessed an increasing interest in neuron-glia communication. This interest stems from the realization that glia participates in cognitive functions and information processing and is involved in many brain disorders and neurodegenerative diseases.
arxiv   +1 more source

An Age-dependent Feedback Control Model for Calcium and Reactive Oxygen Species in Yeast Cells [PDF]

arXiv, 2022
Calcium and reactive oxygen species (ROS) interact with each other and play an important role in cell signaling networks. Based on the existing mathematical models, we develop an age-dependent feedback control model to simulate the interaction. The model consists of three subsystems: cytosolic calcium dynamics, ROS generation from the respiratory chain
arxiv