Results 91 to 100 of about 849,661 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hydrothermal method for preparing calcium phosphate monoliths

Materials Research, 2003
A new hydrothermal route for preparing biphasic calcium phosphate monoliths is proposed. Firstly, a slurry of beta-tricalcium phosphate/ortho-phosphoric acid (b-TCP/H3PO4) is cast into the desired final shape and size to obtain a block composed of ...
Raúl García Carrodeguas, Loreley Morejón Alonso, José Angel Delgado García-Menocal, Lizette Morejón Alonso, María Pau Ginebra Molins, Salvador Martínez Manent, Javier Gil Mur, Jorge Toledo Pérez, José Antonio Planell Estany   +8 more
doaj   +1 more source

Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study

, 2017
The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants.
Ashrafov, A. H, Bolbasov, E. N., Golovkin, A. S., Kozelskaya, A. I., Mishanin, A. I., Novikov, V. A., Shesterikov, E. V., Tverdokhlebov, S. I., Viknianshchukb, A. N.   +8 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification [PDF]

, 2010
In chronic kidney disease (CKD) vascular calcification occurs in response to deranged calcium and phosphate metabolism and is characterized by vascular smooth muscle cell (VSMC) damage and attrition.
Deanfield, J, Figg, N, McNair, R, Rees, L, Schurgers, LJ, Shanahan, CM, Shroff, RC, Skepper, JN   +7 more
core  

Darwinian transformation of a 'scarcely nutritious fluid' into milk [PDF]

, 2012
In an early challenge to an aspect of Darwin’s theory of natural selection, Jackson Mivart contended that milk could not have evolved ‘from a scarcely nutritious fluid from an accidentally hypertrophied cutaneous gland’.
Carver, J.A., Holt, C.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Control of the injectability of calcium carbonate-calcium phosphate mixed cements for bone reconstruction [PDF]

, 2009
The purpose of this study was to improve injectability and cohesiveness of original calcium carbonate-calcium phosphate mixed (CaCO3-CaP) self-setting paste for bone filling and repair.
Combes, Christèle, Girod-Fullana, Sophie, Le Bolay, Nadine, Rey, Christian, Tadier, Solène   +4 more
core  

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling [PDF]

, 2011
Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in
A Tagariello, AK Cheung, AN Kapustin, AP Sage, BA Willems, C Hough, C Surmann-Schmitt, C-H Heldin, CA Gregory, CM Giachelli, CM Shanahan, CM Shanahan, CM Shanahan, CR Dhore, CS Viegas, CS Viegas, CS Viegas, D Proudfoot, E Neven, F Guerrero, F Liu, JL Hunt, KM McCabe, LJ Schurgers, LJ Schurgers, LS Shankman, M Jeune Le, M Mizobuchi, MG Frid, MJ Duer, ML Chatrou, MR Alexander, MS Rafael, MY Speer, N Eitzinger, QQ Huang, R Shroff, RJ Rennenberg, S Feil, S Jono, S Olechnowicz-Tietz, SA Steitz, T Cai, T Lin, VA Jesus Perez de, VP Iyemere, X Li, Y Liu, YJ Lee   +48 more
core   +2 more sources