Results 101 to 110 of about 492,665 (311)

Phosphate-Mediated Regulation of Intracellular Calcium Dynamics

Cells
Phosphate (Pi) and calcium (Ca2+) are essential mineral ions that play coordinated roles in maintaining normal cellular functions. While various steps of calcium signaling are well characterized, emerging evidence suggests the critical role of both ...
Huma Shahzad, Mohammed S. Razzaque
doaj   +1 more source

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Christèle Combes, Briand-Mésange, Fabienne, Fabienne Briand‐Mésange, Combes, Christèle, Gonçalvès, Stéphane, Drouet, Christophe, Stéphane Gonçalvès, Fourmy, Daniel, Swider, Pascal, Rey, Christian, Hélène Autefage, Christophe Drouet, Salles, Jean-Pierre, Sophie Cazalbou, Jean‐Pierre Salles, Cazalbou, Sophie, Pascal Swider, Christian Rey, Autefage, Hélène, Daniel Fourmy   +19 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Preventing Dental Caries with Calcium-Based Materials: A Concise Review

Inorganics
This concise review provides an update on the use of calcium-based materials for the prevention of dental caries. Some calcium-based materials promote remineralization and neutralize bacterial acids, disrupting cariogenic biofilms and inhibiting ...
Jieyi Chen, Yuqing Zhang, Iris Xiaoxue Yin, Ollie Yiru Yu, Alice Kit Ying Chan, Chun Hung Chu   +5 more
doaj   +1 more source

Polymeric additives to enhance the functional properties of calcium phosphate cements

Journal of Tissue Engineering, 2012
The vast majority of materials used in bone tissue engineering and regenerative medicine are based on calcium phosphates due to their similarity with the mineral phase of natural bone. Among them, calcium phosphate cements, which are composed of a powder
Roman A Perez, Hae-Won Kim, Maria-Pau Ginebra   +2 more
doaj   +1 more source

Experimental biphasic Calcium Silicate/Calcium Phosphate cements for direct pulp capping

, 2014
Objectives: MTA cements are hydraulic calcium silicate cements currently used to preserve the vitality of the pulp tissue in direct pulp capping as able to set in the presence of blood and other biological fluids.
SPAGNUOLO, GIANRICO, RICCITIELLO, FRANCESCO, SIBONI F., PROCINO A, PRATI C, RENGO S., GANDOLFI MG   +6 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Precipitation behaviour of calcium phosphate: a model for hard tissue mineralisation

, 1993
Various aspects of the precipitation behaviour of calcium phosphate in aqueous media have been investigated using seeded growth in conjuction with constant-volume and constant-composition techniques under different physical and chemical conditions.
Wong, Alfred T.-C.
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source