Results 51 to 60 of about 1,747,741 (337)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Probing the calcium and sodium local environment in bones and teeth using multinuclear solid state NMR and X-ray absorption spectroscopy [PDF]

, 2010
Despite the numerous studies of bone mineral, there are still many questions regarding the exact structure and composition of the mineral phase, and how the mineral crystals become organised with respect to each other and the collagen matrix.
Newport, Robert J., Melinda, Duer, Smith, Mark E., Wojciech, Chrzanowski, Qiu, D., Robert, Newport, Knowles, J.C., Pickup, D.M., Duer, M.J., Dong, Qiu, Knowles, Jonathan, Wong, Alan, Knowles, Jonathan C., Qiu, Dong, Laurencin, D., Gan, Zhehong, Duer, Melinda J., Smith, M.E., Chrzanowski, W., David, Pickup, Laurencin, Danielle, Pickup, David M., Chrzanowski, Wojciech, Wong, A., Gan, Z.   +24 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calcium Phosphates in Biomedical Engineering

, 2021
In this article a review of the use of Calcium phosphates in Biomedical Engineering has been done. A brief revision of the first applications in the field of medicine of these phosphates is carried out, to later comment on the current situation.
Canillas Pérez, María, Aza Moya, Antonio H. de, Rodríguez Barbero, Miguel Ángel, Maria Canillas, Antonio H. de Aza, Miguel A. Rodríguez   +5 more
core   +1 more source

Phosphate regime of sod-podzolic soil in natural and agrophytocenoses

Бюллетень Почвенного института им. В.В. Докучаева, 2021
The phosphate regime of sod-podzolic soil (heavy loam) of Cis-Urals under natural phytocenoses (mixed forest, cereal-grass meadow) and agrophytocenoses was studied. The influence of agricultural use of arable land on phosphate regime was evaluated in the
M. T. Vasbieva, N. E. Zavyalova
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Interactions between calcium phosphate and heavy metal ions in aqueous solution

MATEC Web of Conferences, 2013
Synthetic and natural calcium phosphates were tested for removal metallic pollution in aqueous solution. Calcium phosphates with Ca/P ratio between 1,33 and 1,67 are fluently called apatite.
Fernane F., Boudia S., Saouli H.
doaj   +1 more source

Fosfatos de cálcio de interesse biológico: importância como biomateriais, propriedades e métodos de obtenção de recobrimentos Calcium phosphates of biological interest: importance as biomaterials, properties and methods for coatings obtaining

Química Nova, 2010
For decades the Hydroxyapatite (HA) was only bioceramic of calcium phosphate system used for bone replacement and regeneration, due to its similarity to the mineral phase of bones and teeth.
Antonio Carlos Guastaldi, Anahi Herrera Aparecida   +1 more
doaj   +1 more source