S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels +7 more
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Crowned dens syndrome presenting as pyrexia of unknown origin (PUO)
Background. Deposition of calcium pyrophosphate crystals in the cervical spine around the odontoid process may lead to neck pain and fever. This condition is called crowned dens syndrome (CDS).
Bansal Agam, Gupta Mohit
doaj +1 more source
The effect of prolonged simulated non- gravitational environment on mineral balance in the adult male, volume 1 Final report [PDF]
Effect of prolonged bed rest with simulated weightlessness on mineral balance in male adult - Vol.
Bayers, J. H. +4 more
core +1 more source
The Complex World of Toothpaste Diversity, Meeting Patient Clinical Needs. An Umbrella Review
ABSTRACT Background Amidst numerous recent advancements in toothpaste formulations and active ingredients, some clinicians may believe all toothpastes are similar despite differences in their active ingredients and corresponding clinical application.
Jeanie Suvan, Crystal Marruganti
wiley +1 more source
Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study
The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants.
Ashrafov, A. H +8 more
core
Erosion Potential of Commercial Fluoride‐Free Mouthwashes on Dental Hard Tissues
ABSTRACT Purpose Mouthwashes often present acidic pH, which raises concerns about their potential contribution to erosive tooth wear. This study evaluated the erosive potential of commercial fluoride‐free mouthwashes using a screening method.
Astrid C. Valdivia‐Tapia +5 more
wiley +1 more source
Haemochromatosis ‐ a modern clinician’s guide
Abstract Haemochromatosis is an inherited disorder of iron metabolism affecting approximately 100 000 Australians. Iron overload may result in end organ dysfunction, most commonly manifesting as chronic liver disease, arthropathy and endocrinopathies. End organ complications can be prevented, minimised or reversed, with early diagnosis and initiation ...
James G. Fiori, John K. Olynyk
wiley +1 more source
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall +4 more
wiley +1 more source
Unusual calcium pyrophosphate deposition disease
Romain, Muller +3 more
openaire +2 more sources

