Results 61 to 70 of about 587,894 (312)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IntCal04 terrestrial radiocarbon age calibration, 0-26 cal kyr BP [PDF]

, 2004
A new calibration curve for the conversion of radiocarbon ages to calibrated (cal) ages has been constructed and internationally ratified to replace ImCal98, which extended from 0-24 cal kyr BP (Before Present, 0 cal BP = AD 1950).
Buck, C. E., Beck, J. Warren,, McCormac, G., Bertrand, C.J.H., Reimer, Ron W.,, Bertrand, Chanda J.H.,, Bertrand, Chanda J. H., Stuiver, Minze,, Guilderson, T., Beck, J. W., Blackwell, Pg, Reimer, R. W., Manning, Sturt W., Fairbanks, R. G., Remmele, S, Hogg, Alan G.,, Fairbanks, Richard G.,, Fairbanks, R., Kromer, B, Buck, C.E., Weyhenmeyer, Constanze E., Beck, J.W., Bard, Edouard, van der Plicht, Johannes, Baillie, Mike G.L.,, Weyhenmeyer, C. E., Ramsey, C.B., Bard, E., McCormac, Gerry,, Damon, P.E., Fairbanks, Rg, Kromer, Bernd, Hughen, K.A., Damon, Paul E., Ramsey, C., Hog, Ag, McCormac, Gerry, Damon, P., Manning, S., Hughen, K. A., Fairbanks, R.G., Bertrand, C, Stuiver, M., Plicht, Johannes van der, Reimer, Paula J., Southon, Jr, Damon, Pe, Guilderson, Tp, Baillie, Mike G.L., Edwards, R. L., Buck, Caitlin E., Blackwell, P.G., Bertrand, Chanda J.H., Remmele, Sabine,, Talamo, S, Talamo, Sahra, Cutler, K. B., Plicht, Johannes van der,, Ramsey, C. B., Talamo, S. ; https://orcid.org/, Taylor, F.W.,, Bronk Ramsey, C, Hughen, Konrad A., Weyhenmeyer, Ce, Reimer, P., Blackwell, Paul G., Ramsey, Christopher Bronk, Taylor, Fw, Friedrich, Michael,, Buck, C., Bayliss, A, Blackwell, Paul G.,, Hogg, Alan G., Blackwell, P. G., Stuiver, Minze, Bayliss, Alex,, Plicht, J,, Taylor, F.W., Plicht, J., Cutler, Kb, Burr, G., Taylor, F., Reimer, Paula J.,, Southon, J., van der Plicht, J., Hogg, A.G., Weyhenmeyer, Constanze E.,, Reimer, Paula; id_orcid, Hughen, Konrad A.,, Baillie, Mgl, Edwards, R. Lawrence, Guilderson, Thomas P.,, Burr, George S.,, Burr, G.S., Weyhenmeyer, C.E., Weyhenmeyer, C., Southon, John R.,, Bertrand, C. J. H., Burr, G. S., Reimer, P. J., Guilderson, T. P., Reimer, Ron, Talamo, Sahra,, Edwards, R., Stuiver, M, Remmele, Sabine, Edwards, R. Lawrence,, Hughen, K., Southon, J.R., Beck, Jw, Southon, John R., Reimer, R., Guilderson, Thomas P., Baillie, M. G. L., Bayliss, A., Reimer, Pj, Manning, S, Cutler, K., Bard, E, Baillie, M., Remmele, S., Edwards, R.L., Bard, Edouard,, Baillie, Mike G. L., Hogg, A. G., Reimer, Ron W., Manning, Sturt,, Manning, Sturt, Bronk Ramsey, Christopher,, Buck, Ce, Plicht, J, van Der, Bayliss, Alex, Bertrand, C., Blackwell, P., Buck, Caitlin E.,, Cutler, Kirsten B.,, Friedrich, M., Burr, George S., Cutler, Kirsten B., Damon, Paul E.,, Burr, Gs, Damon, P. E., Friedrich, Michael, Talamo, S., Reimer, Rw, Kromer, Bernd,, Mccormac, G, Baillie, Michael, Hogg, A., Guilderson, T.P., Beck, J., Kromer, B., Taylor, F. W., Hughen, Ka, Edwards, Rl, Culter, K.B., Beck, J. Warren, Friedrich, M, Bronk Ramsey, Christopher, Fairbanks, Richard G., Southon, J. R.   +160 more
core   +1 more source

Efficient Calibration of Groundwater Contaminant Transport Models Using Bayesian Optimization

Toxics, 2023
Numerical modeling is a significant tool to understand the dynamic characteristics of contaminants transport in groundwater. The automatic calibration of highly parametrized and computationally intensive numerical models for the simulation of contaminant
Hao Deng, Shengfang Zhou, Yong He, Zeduo Lan, Yanhong Zou, Xiancheng Mao   +5 more
doaj   +1 more source

Calibration of Continual Learning Models

2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)
Continual Learning (CL) focuses on maximizing the predictive performance of a model across a non-stationary stream of data. Unfortunately, CL models tend to forget previous knowledge, thus often underperforming when compared with an offline model trained jointly on the entire data stream.
Li, Lanpei, Piccoli, Elia, Cossu, Andrea, Bacciu, Davide, Lomonaco, Vincenzo   +4 more
openaire   +5 more sources

On the calibration of compartmental epidemiological models

CoRR, 2023
Epidemiological compartmental models are useful for understanding infectious disease propagation and directing public health policy decisions. Calibration of these models is an important step in offering accurate forecasts of disease dynamics and the effectiveness of interventions.
Nikunj Gupta, Anh L. Mai, Azza Abouzied, Dennis E. Shasha   +3 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Nearest Correlation-Based Input Variable Weighting for Soft-Sensor Design

Frontiers in Chemistry, 2018
In recent years, soft-sensors have been widely used for estimating product quality or other important variables when online analyzers are not available. In order to construct a highly accurate soft-sensor, appropriate data preprocessing is required.
Koichi Fujiwara, Manabu Kano
doaj   +1 more source

Model Calibration and Validation for the Fuzzy-EGARCH-ANN Model

Applied Computational Intelligence and Soft Computing, 2021
This work shown as the fuzzy-EGARCH-ANN (fuzzy-exponential generalized autoregressive conditional heteroscedastic-artificial neural network) model does not require continuous model calibration if the corresponding DE algorithm is used appropriately, but ...
Geleta T. Mohammed, Jane A. Aduda, Ananda O. Kube   +2 more
doaj   +1 more source

Hyperspectral Empirical Absolute Calibration Model Using Libya 4 Pseudo Invariant Calibration Site

Remote Sensing, 2021
The objective of this paper is to find an empirical hyperspectral absolute calibration model using Libya 4 pseudo invariant calibration site (PICS). The approach involves using the Landsat 8 (L8) Operational Land Imager (OLI) as the reference radiometer ...
Manisha Das Chaity, Morakot Kaewmanee, Larry Leigh, Cibele Teixeira Pinto   +3 more
doaj   +1 more source