Results 171 to 180 of about 12,101 (223)

Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) is a potent, pan‐genotypic inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. Its antiviral activity was evaluated in an ascending dose phase I clinical trial involving 30 patients treated once a day for 7 days. After treatment initiation, plasma HCV RNA declined in a biphasic manner with a mean reduction of 2.3 log10 ...
Carolin Zitzmann   +4 more
wiley   +1 more source

Scope 3 Carbon Emissions Assessment for Manufacturing SMEs

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper addresses the challenges facing managers of Small‐ and Medium‐Size Enterprises (SMEs) when conducting environmental sustainability assessment at the value chain level, particularly Scope 3 Greenhouse Gases (GHG) emissions. The paper investigates issues related to data availability and data quality for Scope 3 assessment and ...
Kourosh Halat   +3 more
wiley   +1 more source

Comparison of Tissue Preparations to Identify and Phenotype T Cells in Human Colorectal Tumor Tissue

open access: yesCytometry Part A, EarlyView.
ABSTRACT Archived patient samples (e.g., formalin‐fixed paraffin embedded (FFPE) tissue blocks, cryoembedded tissue blocks, and frozen whole tissue samples) are a source of immune information for which corresponding patient data is often collected.
Justin F. Tirados   +5 more
wiley   +1 more source

Learning earthquake ground motions via conditional generative modeling. [PDF]

open access: yesNat Commun
Ren P   +11 more
europepmc   +1 more source

An assessment of stress and production rate of sucker rod heat pipes in oil well pumping system

open access: yesDeep Underground Science and Engineering, EarlyView.
The sucker rod pumping system is the preferred oil extraction technique. The concept about equipping the hollow vacuum space in solid sucker rods with heat pipe has been scrutinized in terms of stress and oil production evaluation. Abstract The implementation of the heat pipe concept in sucker rods for oil pumping systems negates the requirement for an
R. S. Anand   +5 more
wiley   +1 more source

Editorial: AI research in cancer pharmacology. [PDF]

open access: yesFront Pharmacol
Choi YC, Calip GS, Kim JM.
europepmc   +1 more source

Research progress and current status of dynamic wave propagation characteristics in rock mass: A review

open access: yesDeep Underground Science and Engineering, EarlyView.
This review elucidates the velocity–dispersion–attenuation coupling mechanisms of wave propagation in rock masses, compares six representative models, and reveals how pressure, temperature, mineral composition, and anisotropy jointly control dynamic responses in complex geological media.
Jiajun Shu   +8 more
wiley   +1 more source

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