Results 81 to 90 of about 38,331 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A Handoff Algorithm of Dynamic Decisions with Extenics for Wireless Cellular Networks

open access: yesJournal of Electrical and Computer Engineering, 2010
A traditional handoff algorithm always adopts stationary channel preservation schemes that cause the increase of call blocking probability (CBP) and the decrease of system utilization to reduce the call dropping probability (CDP) for handoff call.
Chen-Feng Wu
doaj   +1 more source

The unrestricted blocking number in convex geometry

open access: yes, 2010
Let K be a convex body in \mathbb{R}^n. We say that a set of translates \left \{ K + \underline{u}_i \right \}_{i=1}^{p} block K if any other translate of K which touches K, overlaps one of K + \underline{u}_i, i = 1, . . . , p.
Sezgin, S.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Call blocking in multi-services systems on one transmission link [PDF]

open access: yes, 2000
Future broadband integrated services digital networks (B-ISDN) are expected to use the Asynchronous Transfer Mode (ATM) technology and support multiple services. In the multiservices context, three Connection Admission Control (CAC) strategies with guaranteed Grade of Services (GoS)are presented: Complete Sharing (CS), Complete Sharing with ...
Myriam Delaire, Gérard Hébuterne
openaire   +1 more source

Performance analysis of call admission control algorithm for wireless multimedia networks

open access: yes, 2011
In todays wireless networks different wireless multimedia services have diverse bandwidth and QOS requirements, which need to be guaranteed by the wireless cellular networks. The decision to admit or reject the new user call is made by the call admission
S.P.V Subbarao, Dr.D.Sreenivasa Rao
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Criminal Behaviour Associated with a Novel Mutation in the VPS13A-Gene Causing Chorea-Acanthocytosis

open access: yesCase Reports in Psychiatry, 2019
Heralded by obsessive-compulsive disorder and anxiety, chorea-acanthocytosis may initially present in a psychiatric setting. As insidious onset of involuntary movements is commonly precipitated by dopamine blocking agents, this may not prompt further ...
Søren Bruno Elmgreen
doaj   +1 more source

A connection-level call admission control using genetic algorithm for MultiClass multimedia services in wireless networks

open access: yes, 2006
Call admission control in a wireless cell in a personal communication system (PCS) can be modeled as an M/M/C/C queuing system with m classes of users. Semi-Markov Decision Process (SMDP) can be used to optimize channel utilization with upper bounds on ...
Ni, Q, Hong, X, Xiao, Y
core  

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